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长链非编码RNAHOTAIR在血液系肿瘤中的研究进展
作者:赵雪梅1  王季石2  朱红倩1 
单位:1. 贵州省人民医院 血液科, 贵州 贵阳 550002;
2. 贵州医科大学附属医院 血液科, 贵州 贵阳 550000
关键词:长链非编码RNA 同源异型盒基因转录反义基因间RNA 白血病 多发性骨髓瘤 淋巴瘤 综述 
分类号:R733
出版年·卷·期(页码):2021·49·第十一期(1359-1365)
摘要:

长链非编码RNA(lncRNAs)是一类转录本长度>200个核苷酸的重要新型非编码RNAs,其中同源异型盒基因转录反义基因间RNA(HOTAIR)是研究最广泛的lncRNAs之一。HOTAIR在染色质重塑、转录及转录后水平调控基因表达等方面具有重大意义,参与表观遗传调控、蛋白质泛素化、能量代谢、自噬、炎症免疫反应等过程。最近研究发现,在白血病、多发性骨髓瘤、淋巴瘤等血液系肿瘤中,HOTAIR表达存在改变,可能与这些疾病的发生、发展密切相关。本文就HOTAIR的起源、结构、作用机制及在血液肿瘤中的研究进展进行综述,为血液肿瘤的诊治和评估预后等提供新思路。

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