目的：探讨环状RNA 0010729（circ_0010729）是否靶向调控miR-330-5p影响白细胞介素（IL-1β）诱导的软骨细胞损伤。方法：实时定量PCR （RT-qPCR）分析IL-1β诱导后软骨细胞中circ_0010729和miR-330-5p表达量。双荧光素酶报告实验和RT-qPCR确定circ_0010729对miR-330-5p的靶向调控作用。流式细胞术分析circ_0010729和miR-330-5p表达对IL-1β诱导软骨细胞凋亡的影响。试剂盒测定IL-6和γ干扰素（IFN-γ）水平。蛋白质印迹法（Western blotting）分析Bcl-2和Bax表达量。结果：IL-1β诱导后软骨细胞中circ_0010729表达量显著升高（P<0.05），而miR-330-5p表达量显著降低（P<0.05）。circ_0010729可通过与miR-330-5p特异性结合并负调控miR-330-5p表达。抑制circ_0010729或过表达miR-330-5p显著降低IL-1β诱导的软骨细胞凋亡，下调Bax蛋白表达，上调Bcl-2蛋白表达，降低IL-6和IFN-γ水平（P<0.05）。下调miR-330-5p表达显著减弱抑制circ_0010729对IL-1β诱导的软骨细胞凋亡以及炎症反应的影响（P<0.05）。结论：抑制circ_0010729通过靶向miR-330-5p能够减弱IL-1β诱导的软骨细胞损伤。

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