新诊断2型糖尿病患者血清Maresin 1水平检测及其临床意义-现代医学

新诊断2型糖尿病患者血清Maresin 1水平检测及其临床意义

作者：李惠平¹ 李凌² 陈莉³ 周雯³ 周倩³ 徐琳³ 黄春苓³ 陈定宇³ 何凌³

单位：1. 广州市第一人民医院/华南理工大学附属第二医院老年病科, 广东广州 510180;
2. 广州市第一人民医院/华南理工大学附属第二医院病案管理科, 广东广州 510180;
3. 广州市第一人民医院/华南理工大学附属第二医院内分泌科, 广东广州 510180

关键词：2型糖尿病 Maresin 1水平胰岛素抵抗

分类号：R587.1

出版年·卷·期（页码）：2021·49·第十期（1138-1143）

摘要：

目的：检测新诊断2型糖尿病（T2DM）患者血清Maresin 1水平并探讨其与T2DM患病风险的相关性。方法：纳入2016年5月至2017年9月在广州市第一人民医院内分泌科门诊及住院的新诊断T2DM患者118例为病例组，选择同期该院体检中心的健康体检者115例为对照组，记录一般临床资料，检测两组对象血液生化指标、空腹C肽（FCP）、糖化血红蛋白（HbA1C）及血清Maresin 1水平，计算胰岛素抵抗指数，分析两组之间各参数的差异，用单因素及多因素Logistic回归分析探讨T2DM患病的影响因素，通过构建受试者工作特征（ROC）曲线，计算曲线下面积（AUC）来评估回归模型对T2DM患病风险的识别能力。结果：病例组收缩压（SBP）、舒张压（DBP）、腰臀比（WHR）、空腹血糖（FPG）、FCP、甘油三酯（TG）、HbA1C和胰岛素抵抗指数水平高于对照组；饮酒比例、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和Maresin 1水平低于对照组；相关分析提示Maresin 1水平与DBP、TG、HbA1C水平呈负相关；单因素Logistic回归分析发现SBP、DBP、WHR、TG、TC、LDL-C、HDL-C、Maresin 1及饮酒史可能是T2DM患病的影响因素，多因素Logistic回归分析逐步选择法发现饮酒史、WHR、HDL-C及Maresin 1是T2DM患病的影响因素。回归模型的AUC是0.81（95%CI：0.76~0.87），该模型的AUC在不同性别、年龄分组中差异无统计学意义。结论：新诊断T2DM患者血清Maresin 1水平降低，且Maresin 1水平可能与T2DM的患病风险相关。

Objective: To detect the serum Maresin 1 level in newly diagnosed type 2 diabetes mellitus(T2DM) patients and to explore its correlation with the risk of T2DM.Methods: 118 newly diagnosed T2DM patients in the department of endocrinology in Guangzhou First People's Hospital from May 2016 to September 2017 were selected as case group,and 115 healthy physical examiners in the physical examination center of the hospital in the same period were selected as control group. General clinical data were recorded, blood biochemical indexes, fasting C-peptide(FCP), glycosylated hemoglobin A1C(HbA1C), the serum Maresin 1 level were measured and insulin resistance index(IR) was calculated. The differences between the two groups were analyzed. Univariate and multivariate Logistic regression analysis were used to screen the possible influencing factors of T2DM. The value of the regression model to identify the risk of T2DM was estimated by constructing the receiver operating characteristic(ROC) curve and calculating the area under the curve(AUC). Results: Higher levels of systolic blood pressure(SBP), diastolic blood pressure(DBP), waist-to-hip ratio(WHR), fasting plasma glucose(FPG), FCP, triglyceride(TG), HbA1C and IR were detected in case group than control group. Lower levels of alcohol consumption ratio, total cholesterol(TC), low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C) and Maresin 1 were detected in case group than control group. Correlation analysis showed that the level of Maresin-1 was negatively correlated with DBP, TG and HbA1C. Univariate Logistic regression analysis showed that SBP, DBP, WHR, TG, TC, LDL-C, HDL-C, Maresin 1 and drinking history may be the influencing factors of T2DM. Multivariate Logistic regression analysis showed that drinking history, WHR, HDL-C and Maresin 1 levels were the influencing factors of T2DM. AUC of the regression model is 0.81(95% credibility interval:0.76-0.87), and there was no statistical difference in the AUC of the model among different gender and age groups.Conclusions: The level of serum Maresin 1 is decreased in newly diagnosed T2DM patients and Maresin 1 may be associated with the risk of T2DM.

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