[1] World Health Organization.Obesity and overweight[EB/OL].[2021-07-08].https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.
[2] GBD 2017 Risk Factor Collaborators.Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017:a systematic analysis for the global burden of disease study 2017[J]. Lancet, 2018, 392(10159):1923-1994.
[3] KOTCHEN T A.Obesity-related hypertension:epidemiology, pathophysiology, and clinical management[J]. Am J Hypertens, 2010, 23(11):1170-1178.
[4] 孙志, 张中成, 刘志诚.营养性肥胖动物模型的实验研究[J]. 中国药理学通报, 2002, 18(4):466-467.
[5] LEVIN B E.Arcuate NPY neurons and energy homeostasis in diet-induced obese and resistant rats[J]. Am J Physiol, 1999, 276(2):382-387.
[6] DESIMONE G, LZZO R, DELUCA N, et al. Left ventricular geometry in obesity:is it what we expect?[J]. Nutr Metab Cardiovasc Dis, 2013, 23(10):905-912.
[7] CORAZZARI M, GAGLIARDI M, FIMIA G M, et al. Endoplasmic reticulum stress, unfolded protein response, and cancer cell fate[J]. Front Oncol, 2017, 7:78.
[8] OLIVARES-SLILVA F, ESPITIA-CORREDOR J, LETELIER A, et al. TGF-β1 decreases CHOP expression and prevents cardiac fibroblast apoptosis induced by endoplasmic reticulum stress[J]. Toxicol In Vitro, 2020, 70:105041.
[9] XIONG Y, WANG Y, XIONG Y, et al. Salidroside alleviated hypoxia-induced liver injury by inhibiting endoplasmic reticulum stress-mediated apoptosis via IRE1α/JNK pathway[J]. Biochem Biophys Res Commun, 2020, 529(2):335-340.
[10] NAIEL S, CARLISLE RE, LU C, et al. Endoplasmic reticulum stress inhibition blunts the development of essential hypertension in the spontaneously hypertensive rat[J]. Am J Physiol Heart Circ Physiol, 2019, 316(5):H1214-H1223.
[11] KHADIR A, KAVALAKATT S, ABUBAKER J, et al. Physical exercise alleviates ER stress in obese humans through reduction in the expression and release of GRP78 chaperone[J]. Metabolism, 2016, 65(9):1409-1420.
[12] KAWASAKI N, ASADA R, SAITO A, et al. Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue[J]. Sci Rep, 2012, 2:799.
[13] OZCAN U, YILMAZ E, OZCAN L, et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes[J]. Science, 2006, 313(5790):1137-1140.
[14] CHE Y, WANG Z P, YUAN Y, et al. Role of autophagy in a model of obesity:a long-term high fat diet induces cardiac dysfunction[J]. Mol Med Rep, 2018, 18(3):3251-3261.
[15] LI S J, LIU C H, CHU H P, et al. The high-fat diet induces myocardial fibrosis in the metabolically healthy obese minipigs-the role of ER stress and oxidative stress[J]. Clin Nutr, 2017, 36(3):760-767.
[16] TIAN J H, WU Q, HE Y X, et al. Zonisamide, an antiepileptic drug, alleviates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress[J]. Acta Pharmacol Sin, 2021, 42(3):393-403.
[17] 芦波, 符德玉, 韩亚楠, 等.中心性肥胖高血压患者左室肥厚危险因素分析[J]. 中国循证心血管医学杂志, 2020, 12(3):285-289.
[18] MCGRATH K C, HEATHER A K.Endoplasmic reticulum stress in inflammatory disease[J]. Endocrinology, 2012, 153(7):2949-2952.
[19] OKADA K, MINAMINNO T, TSUKAMOTO Y, et al. Prolonged endoplasmic reticulum stress in hypertrophic and failing heart after aortic constriction:possible contribution of endoplasmic reticulum stress to cardiac myocyte apoptosis[J]. Circulation, 2004, 110(6):705-712.
[20] FU H Y, OKADA K, LIAO Y L, et al. Ablation of c/ebp homologous protein attenuates endoplasmic reticulum-mediated apoptosis and cardiac dysfunction induced by pressure overload[J]. Circulation, 2010, 122(4):361-369.
[21] SUN Y Y, LIU G H, SONG T, et al. Upregulation of GRP78 and caspase-12 in diastolic failing heart[J]. Acta Biochim Pol, 2008, 55(3):511-516.
[22] SABIRLI R, KOSELER A, MANSUR N, et al. Predictive value of endoplasmic reticulum stress markers in low ejection fractional heart failure[J]. In Vivo, 2019, 33(5):1581-1592.
[23] LI J, KEMP B A, HOWELL N L, et al. Metabolic changes in spontaneously hypertensive rat hearts precede cardiac dysfunction and left ventricular hypertrophy[J]. J Am Heart Assoc, 2019, 8(4):e010926.
[24] RADWAN E, BAKR M H, TAHA S, et al. Inhibition of endoplasmic reticulum stress ameliorates cardiovascular injury in a rat model of metabolic syndrome[J]. J Mol Cell Cardiol, 2020, 143:15-25.
[25] BAL N B, HAN S, KIREMITCI S, et al. Hypertension-induced cardiac impairment is reversed by the inhibition of endoplasmic reticulum stress[J]. J Pharm Pharmacol, 2019, 71(12):1809-1821.
[26] GE Y, LI G, LIU B, et al. The protective effect of lacidipine on myocardial remodeling is mediated by the suppression in expression of GPR78 and CHOP in rats[J]. Evid Based Complement Alternat Med, 2015, 2015:945076.
[27] WU Y, YUE Y, FU S, et al. Icariside Ⅱ prevents hypertensive heart disease by alleviating endoplasmic reticulum stress via the PERK/ATF-4/CHOP signalling pathway in spontaneously hypertensive rats[J]. J Pharm Pharmaocol, 2019, 71(3):400-407. |