目的：探讨南京某高校教职工非酒精性单纯性脂肪肝（NAFL）患病率及与估算的肾小球滤过率（eGFR）相关性。方法：以某高校2019年5~12月健康体检的教职工为研究对象，检测一般资料、生化指标及肝脏超声。结果：2 068例受试者，NAFL患者736例，患病率为35.59%，随年龄增加男性NAFL患病率有上升趋势（P<0.001），60岁以下男性NAFL患病率高于女性（P<0.05）；与非NAFL组相比，NAFL组具有较高的体重指数（BMI）、腰围、收缩压、舒张压、丙氨酸氨基转移酶（ALT）、空腹血糖（GLU）、尿素氮（Urea）、肌酐（CR）、尿酸（UA）、甘油三酯（TG）、胆固醇（TC）、低密度脂蛋白（LDL-C）和较低的高密度脂蛋白（HDL-C）、eGFR值（P<0.05）；多因素Logistic回归分析显示肥胖、腹型肥胖、肝功能异常、高TG、低HDL-C、eGFR下降为NAFL发生的危险因素（P<0.01）。eGFR与BMI、腰围、ALT、TG呈负相关（P<0.05），与HDL-C呈正相关（P<0.001），校正年龄、性别后，上述相关仍存在（P<0.001）。结论：NAFL与eGFR存在相关性，两者之间相互影响。临床上应注意NAFL和慢性肾脏病的综合预防、诊断和干预，以期降低心血管疾病等不良事件发生风险。

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