Objective: To study the relationship between PAM50 gene mutation and the curative effect of breast cancer patients undergoing immediate breast reconstruction and its predictive value for postoperative survival. Methods: 124 patients with breast cancer in Xingtai Third Hospital from August 2016 to August 2017 were selected and treated with immediate breast reconstruction. The patients age, pathological type, clinical benefit, progression free survival time, PAM50 gene mutation were collected. According to with or withoutPAM50 gene mutation, they were divided into mutation group and non-mutation group, and the differences of medical records between the two groups were compared. Multivariate Logistic regression analysis was used to analyze the risk factors affecting the treatment efficacy of breast cancer. Receiver operating characteristic(ROC) curve was used to analyze the value of PAM50 gene mutation in predicting postoperative survival. Results: Among the 124 breast cancer patients, 28 (22.58%) had PAM50 gene mutation, and the clinical benefit rate and progression free survival time of the mutation group were significantly lower than or shorter than those of the non-mutation group(P<0.05). Logistic regression analysis showed that PAM50 gene mutation(OR=2.146,95%CI 1.198-3.831)and TNM stage(OR=2.846,95%CI 1.230-6.586)wererisk factors of treatment effect(P< 0.05). After following up 3 years, 45 cases(36.29%) died, including 15 cases (53.57%) in mutation group and 30 cases (31.25%) in non-mutation group. The mortality difference between the two groups was statistically significant (χ2=4.671, P=0.031). ROC curve analysis showed that the AUC of PAM50 gene mutation predicting 3-year survival was 0.813 (95%CI 0.752-0.896), and the specificity and sensitivity were 76.6% and 77.8%, respectively.Conclusion: PAM50 gene mutation, which has high predictive value for postoperative survival, in breast cancer patients is a risk factor affecting the treatment efficacy of immediate breast reconstruction. |
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