网站首页期刊介绍通知公告编 委 会投稿须知电子期刊广告合作联系我们
最新消息:
颅内动脉钙化的分布与脑小血管疾病影像学表现的相关性研究
作者:唐亚运  吴平  许亚春 
单位:南通大学附属海安医院 影像科, 江苏 海安 226600
关键词:颅内动脉钙化 脑小血管疾病 磁共振成像 计算机断层扫描 
分类号:R743
出版年·卷·期(页码):2021·49·第五期(525-530)
摘要:

目的:探讨颅内动脉钙化的分布与脑小血管疾病(CSVD)磁共振成像(MRI)表现的相关性。方法:选取2017年6月至2019年6月来我院就诊行CT和MRI检查的腔隙性梗死或脑白质病变患者150例;采用Agatston积分法对颅内动脉钙化进行评分,采用MRI评估脑梗死、脑白质高信号(WMH)、腔隙灶、脑微出血(CMB)、脑内扩大的血管周围间隙(EPVS)情况。结果:109例(72.67%)患者发现颅内动脉钙化,以颈内动脉(ICA)发生率最高(64.7%)。颅内动脉钙化的严重程度与WMH、腔隙灶及CMB具有相关性(分别r=0.348、r=0.284、r=0.250,均P<0.05),与EPVSs无相关性(r=0.141,P=0.057);颅内动脉钙化调整的比值比(OR)为:WMH (1~2级)OR=2.745、WMH (3级)OR=3.421、腔隙灶OR=2.901、CMB OR=2.448、EPVS (1级)OR=0.870、EPVS (2~4级)OR=0.294。结论:颅内动脉钙化在CSVD患者中较为常见,颅内动脉钙化与WMH、腔隙灶、CMB密切相关,可作为预测CSVD的重要指标。

Objective: To investigate the correlation between the distribution of intracranial arterial calcification and magnetic resonance imaging(MRI) findings of cerebral small vessel disease(CSVD).Methods: A total of 150 patients who visited our Hospitalbetween June 2017 and June 2019 and underwent CT and MRI examinations for lacunar infarction or white matter lesions were included in this study. The intracranial artery calcification was evaluated with the Agatston integral method. MRI was used to evaluate cerebral infarction, white matter hyperintensities(WMH), lacuna, cerebral microbleed(CMB), and intracerebral enlarged perivascular spaces(EPVS).Results: Intracranial artery calcification was found in 109 patients(72.67%), with the incidence of internal carotid artery(ICA) being the highest(64.7%). The severity of intracranial arterial calcification was correlated with WMH, lacuna, and CMB(r=0.348, r=0.284, r=0.250; P<0.05), but there was no correlation with EPVS(r=0.141; P=0.057). Adjusted odds ratios(OR) for intracranial arterial calcification were WMH(Grades 1-2)OR=2.745, WMH(Grade 3)OR=3.421, lacunaOR=2.901, CMB OR=2.448, EPVS(Grade 1) OR=0.870, and EPVS(Grades 2-4)OR=0.294.Conclusion: Intracranial artery calcification is common in patients with CSVD. Intracranial artery calcification is closely related to WMH,lacuna and CMB, all of which could be used as an important indices for predicting CSVD.

参考文献:

[1] FOKS A C,BOT I.Preface:pathology and pharmacology of atherosclerosis[J].Eur J Pharmacol,2017,816:1-2.
[2] DURHAM A L,SPEER M Y,SCATENA M,et al.Role of smooth muscle cells in vascular calcification:implications in atherosclerosis and arterial stiffness[J].Cardiovasc Res,2018,114(4):590-600.
[3] BOS D,LEENING M J,KAVOUSI M,et al.Comparison of atherosclerotic calcification in major vessel beds on the risk of all-cause and cause-specific mortality:the rotterdam study[J].Circ Cardiovasc Imaging,2015,8(12).e003843.
[4] COUTINHO J M,DERKATCH S,POTVIN A R,et al.Carotid artery web and ischemic stroke:a case-control study[J].Neurology,2017,88(1):65-69.
[5] COMPAGNE K C J,CLEPHAS P R D,MAJOIE C,et al.Intracranial carotid artery calcification and effect of endovascular stroke treatment[J].Stroke,2018,49(12):2961-2968.
[6] 周博锋,张为.脑小血管病所致认知障碍的研究进展[J].广西中医药大学学报,2019,22(3):49-51.
[7] 王艺静,孙艳秋.脑小血管病影像学研究进展[J].分子影像学杂志,2017,40(4):478-481.
[8] CANNISTRARO R J,BADI M,EIDELMAN B H,et al.CNS small vessel disease:a clinical review[J].Neurology,2019,92(24):1146-1156.
[9] WARDLAW J M,SMITH E E,BIESSELS G J,et al.Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration[J].Lancet Neurol,2013,12(8):822-838.
[10] LEBEDEVA E R,GURARY N M,OLESEN J.New diagnostic criteria for headache attributed to transient ischemic attacks[J].J Headache Pain,2019,20(1):97.
[11] TEASELL R,HUSSEIN N,MCCLURE A,et al.Stroke:more than a 'brain attack'[J].Int J Stroke,2014,9(2):188-190.
[12] KUMAR V,MIN J K,HE X,et al.Computation of calcium score with dual-energy computed tomography:a phantom study[J].J Comput Assist Tomogr,2017,41(1):156-158.
[13] RUMBERGER J A,BRUNDAGE B H,RADER D J,et al.Electron beam computed tomographic coronary calcium scanning:a review and guidelines for use in asymptomatic persons[J].Mayo Clin Proc,1999,74(3):243-252.
[14] FAZEKAS F,CHAWLUK J B,ALAVI A,et al.MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging[J].AJR Am J Roentgenol,1987,149(2):351-356.
[15] CHUNG P W,PARK K Y,MOON H S,et al.Intracranial internal carotid artery calcification:a representative for cerebral artery calcification and association with white matter hyperintensities[J].Cerebrovasc Dis,2010,30(1):65-71.
[16] DEL BRUTTO O H,MERA R M.Enlarged perivascular spaces in the basal ganglia are independently associated with intracranial atherosclerosis in the elderly[J].Atherosclerosis,2017,267:34-38.
[17] KONTON S,TASHLYKOV V,SCHWAMMENTHAL Y,et al.Cerebral artery calcification in patients with acute cerebrovascular diseases:determinants and long-term clinical outcome[J].Eur J Neurol,2012,19(5):739-745.
[18] 仪忠俊,董保华,牛兆青,等.低密度脂蛋白胆固醇在脑小血管病中的临床意义及其与患者认知水平的关系[J].东南大学学报(医学版),2018,37(1):113-118.

服务与反馈:
文章下载】【发表评论】【查看评论】【加入收藏
提示:您还未登录,请登录!点此登录
您是第 472192 位访问者


 ©《现代医学》编辑部
联系电话:025-83272481;83272479
电子邮件: xdyx@pub.seu.edu.cn

苏ICP备09058541