颅内动脉钙化的分布与脑小血管疾病影像学表现的相关性研究-现代医学

颅内动脉钙化的分布与脑小血管疾病影像学表现的相关性研究

单位：南通大学附属海安医院影像科, 江苏海安 226600

分类号：R743

出版年·卷·期（页码）：2021·49·第五期（525-530）

摘要：

目的：探讨颅内动脉钙化的分布与脑小血管疾病（CSVD）磁共振成像（MRI）表现的相关性。方法：选取2017年6月至2019年6月来我院就诊行CT和MRI检查的腔隙性梗死或脑白质病变患者150例；采用Agatston积分法对颅内动脉钙化进行评分，采用MRI评估脑梗死、脑白质高信号（WMH）、腔隙灶、脑微出血（CMB）、脑内扩大的血管周围间隙（EPVS）情况。结果：109例（72.67%）患者发现颅内动脉钙化，以颈内动脉（ICA）发生率最高（64.7%）。颅内动脉钙化的严重程度与WMH、腔隙灶及CMB具有相关性（分别r=0.348、r=0.284、r=0.250，均P<0.05），与EPVSs无相关性（r=0.141，P=0.057）；颅内动脉钙化调整的比值比（OR）为：WMH （1～2级）OR=2.745、WMH （3级）OR=3.421、腔隙灶OR=2.901、CMB OR=2.448、EPVS （1级）OR=0.870、EPVS （2～4级）OR=0.294。结论：颅内动脉钙化在CSVD患者中较为常见，颅内动脉钙化与WMH、腔隙灶、CMB密切相关，可作为预测CSVD的重要指标。

Objective: To investigate the correlation between the distribution of intracranial arterial calcification and magnetic resonance imaging(MRI) findings of cerebral small vessel disease(CSVD).Methods: A total of 150 patients who visited our Hospitalbetween June 2017 and June 2019 and underwent CT and MRI examinations for lacunar infarction or white matter lesions were included in this study. The intracranial artery calcification was evaluated with the Agatston integral method. MRI was used to evaluate cerebral infarction, white matter hyperintensities(WMH), lacuna, cerebral microbleed(CMB), and intracerebral enlarged perivascular spaces(EPVS).Results: Intracranial artery calcification was found in 109 patients(72.67%), with the incidence of internal carotid artery(ICA) being the highest(64.7%). The severity of intracranial arterial calcification was correlated with WMH, lacuna, and CMB(r=0.348, r=0.284, r=0.250; P<0.05), but there was no correlation with EPVS(r=0.141; P=0.057). Adjusted odds ratios(OR) for intracranial arterial calcification were WMH(Grades 1-2)OR=2.745, WMH(Grade 3)OR=3.421, lacunaOR=2.901, CMB OR=2.448, EPVS(Grade 1) OR=0.870, and EPVS(Grades 2-4)OR=0.294.Conclusion: Intracranial artery calcification is common in patients with CSVD. Intracranial artery calcification is closely related to WMH,lacuna and CMB, all of which could be used as an important indices for predicting CSVD.

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