尼妥珠单抗联合放射治疗对老年食管鳞癌患者的疗效分析-现代医学

尼妥珠单抗联合放射治疗对老年食管鳞癌患者的疗效分析

单位：南京中医药大学附属医院放疗科, 江苏南京 210029

分类号：R735.1

出版年·卷·期（页码）：2021·49·第五期（511-514）

摘要：

目的：探讨尼妥珠单抗联合放疗对老年食管鳞癌患者治疗的有效性和安全性。方法：选取2015年5月至2016年4月我院收治的27例病理确诊为食管鳞癌、年龄>70岁的患者为研究对象。患者不适合或拒绝手术及化疗而予尼妥珠单抗联合单纯放疗。患者行调强放疗同期使用尼妥珠单抗200 mg·周^-1。评估临床疗效、毒副作用及远期生存情况。结果：27例患者均完成治疗计划。中位生存期及中位无进展生存期分别为17.0个月和16.0个月；2年和3年的总生存率分别为49.6%和37.2%，无疾病进展率分别为45.6%和21.4%。患者疗程中均出现1～2度放射性食管炎，无3度以上食管炎及血液学毒性发生。结论：尼妥珠单抗联合单纯放疗对老年食管鳞癌患者安全有效，但仍需扩大样本量进一步研究证实。

Objective: To investigate the effectiveness and safety of nitrozumab combined with radiotherapy in elderly patients with esophageal squamous carcinoma. Methods: 27 cases with pathologically confirmed esophageal squamous carcinoma(>70 years old) admitted to our hospital between May 2015 and April 2016 were selected for the study. Patients were unfit for or refused surgery and chemotherapy, and were treated solely with nitrozumab combined with radiotherapy. All patients were treated with intensity-modulated radiotherapy, and nitrozumab(200 mg·week^-1) was administered along with radiotherapy. Clinical outcome, toxicities and long-term survival rates were assessed.Results: All 27 patients completed the treatment plan. The median survival and median progression-free survival were 17.0 months and 16.0 months, respectively. The overall survival at 2 and 3 years were 49.6% and 37.2%, respectively, and the rates of progression-free patients were 45.6% and 21.4% respectively. All patients developed radiation oesophagitis of degree 1 to 2 during the course of treatment, with no occurrence of oesophagitis above degree 3 or haematological toxicity.Conclusion: Nitrozumab combined with radiotherapy alone is safe and effective in treating elderly patients with esophageal squamous carcinoma, but further studies with expanded sample sizes are needed to consolidate this finding.

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