Objective: To investigate the expression and clinical significance of CCN5 protein in breast intraductal hyperplastic lesions and breast cancer. Methods: CCN5 was expressed in 20 cases of normal breast tissue(NBT),110 cases of intraductal hyperplasia of breast including 20 cases of usual ductal hyperplasia(UDH), 30 cases of atypical ductal hyperplasia(ADH), 60 cases of ductal carcinoma in situ(DCIS), and 90 cases of invasive lesions(IL) including 60 cases of invasive ductal carcinoma(IDC) and 30 cases of lymph node metastasis(LNM) by immunohistochemical SP method. The relationship between breast cancer and clinicopathological parameters was analyzed.Results: Expression rates of CCN5 protein were 10.00%(2/20),15.00%(3/20), 73.33%(22/30), 71.67%(43/60), 35.00%(21/60) and 16.67%(5/30) in NBT,UDH, ADH, DCIS, IDC, and LNM respectively, and the differences among them were statistically significant(χ2=56.785, P<0.001). Expression rates of CCN5 protein in NBT, intraductal hyperplastic lesions,and IL were 10.00%(2/20), 61.82%(8/110) and 28.89%(6/90) respectively, and the differences were statistically significant(χ2=31.944, P<0.001). Expression rates of CCN5 protein were significantly different(P<0.05) in IDC with different ER, PR, pathological grade, tumor diameter, vascular tumor thrombus and lymph node metastasis, but were not significantly affected by age or location(P>0.05).Conclusion: With the development of breast ductal epithelial from UDH to LNM, the expression rate of the CCN5 protein gradually decreases, suggesting that the CCN5 expression is related to the occurrence and clinical progress of intraductal proliferative lesions and breast cancer. This result may provide a new theoretical basis for diagnosis, clinical treatment and prognosic evaluation of breast cancer and precancerous lesions.
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