[1] 郑荣寿,孙可欣,张思维,等.2015年中国恶性肿瘤流行情况分析[J].中华肿瘤杂志,2019,41(1):19-28.
[2] 钟云华,范敏娟.血浆中抑癌基因MGMT、P16、CDH13和RASSFIA甲基化在肺癌诊断中的作用[J].东南大学学报(医学版),2019,38(2):333-337.
[3] TORRE L A,BRAY F,SIEGEL R L,et al.Global cancer statistics,2012[J].CA Cancer J Clin,2015,65(2):87-108.
[4] ARBOUR K C,RIELY G J.Systemic therapy for locally advanced and metastatic non-small cell lung cancer:a review[J].JAMA,2019,322(8):764-774.
[5] YANG Z,KLIONSKY D J.Mammalian autophagy:core molecular machinery and signaling regulation[J].Curr Opin Cell Biol,2010,22(2):124-131.
[6] ONORATI A V,DYCZYNSKI M,OJHA R,et al.Targeting autophagy in cancer[J].Cancer,2018,124(16):3307-3318.
[7] XILOURI M,STEFANIS L.Chaperone mediated autophagy to the rescue:a new-fangled target for the treatment of neurodegenerative diseases[J].Mol Cell Neurosci,2015,66(3):29-36.
[8] ZOU Y,LING Y H,SIRONI J,et al.The autophagy inhibitor chloroquine overcomes the innate resistance of wild-type EGFR non-small-cell lung cancer cells to erlotinib[J].J Thorac Oncol,2013,8(6):693-702.
[9] ROTOW J,BIVONA T G.Understanding and targeting resistance mechanisms in NSCLC[J].Nat Rev Cancer,2017,17(11):637-658.
[10] WHITE E.Deconvoluting the context-dependent role for autophagy in cancer[J].Nat Rev Cancer,2012,12(6):401-410.
[11] IWAHARA T,FUJIMOTO J,WEN D,et al.Molecular characterization of ALK,a receptor tyrosine kinase expressed specifically in the nervous system[J].Oncogene,1997,14(4):439-449.
[12] HALLBERG B,PALMER R H.Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology[J].Nat Rev Cancer,2013,13(10):685-700.
[13] ROSKOSKI R.Anaplastic lymphoma kinase (ALK):structure,oncogenic activation,and pharmacological inhibition[J].Pharmacol Res,2013,68(1):68-94.
[14] SOLOMON B J,MOK T,KIM D W,et al.First-line crizotinib versus chemotherapy in ALK-positive lung cancer[J].N Engl J Med,2014,371(23):2167-2177.
[15] MITOU G,FRENTZEL J,DESQUESNES A,et al.Targeting autophagy enhances the anti-tumoral action of crizotinib in ALK-positive anaplastic large cell lymphoma[J].Oncotarget,2015,6(30):30149-30164.
[16] SANG J,ACQUAVIVA J,FRIEDLAND J C,et al.Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer[J].Cancer Discov,2013,3(4):430-443.
[17] JI C,ZHANG L,CHENG Y,et al.Induction of autophagy contributes to crizotinib resistance in ALK-positive lung cancer[J].Cancer Biol Ther,2014,15(5):570-577.
[18] YOU L,SHOU J,DENG D,et al.Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines[J].Oncotarget,2015,6(37):40268-40282.
[19] LYNCH T J,BELL D W,SORDELLA R,et al.Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib[J].N Engl J Med,2004,350(21):2129-2139.
[20] PAEZ J G,JÄNNE P A,LEE J C,et al.EGFR mutations in lung cancer:correlation with clinical response to gefitinib therapy[J].Science,2004,304(5676):1497-1500.
[21] CHAN B A,HUGHES B G.Targeted therapy for non-small cell lung cancer:current standards and the promise of the future[J].Transl Lung Cancer Res,2015,4(1):36-54.
[22] LI Y Y,LAM S K,ZHENG C Y,et al.The effect of tumor microenvironment on autophagy and sensitivity to targeted therapy in EGFR-mutated lung adenocarcinoma[J].J Cancer,2015,6(4):382-386.
[23] YUAN J,ZHANG N,YIN L,et al.Clinical implications of the autophagy core gene variations in advanced lung adenocarcinoma treated with gefitinib[J].Sci Rep,2017,7(1):17814.
[24] SAKUMA Y,MATSUKUMA S,NAKAMURA Y,et al.Enhanced autophagy is required for survival in EGFR-independent EGFR-mutant lung adenocarcinoma cells[J].Lab Invest,2013,93(10):1137-1146.
[25] NIHIRA K,MIKI Y,IIDA S,et al.An activation of LC3A-mediated autophagy contributes to de novo and acquired resistance to EGFR tyrosine kinase inhibitors in lung adenocarcinoma[J].J Pathol,2014,234(2):277-288.
[26] WEI Y,ZOU Z,BECKER N,et al.EGFR-mediated Beclin 1 phosphorylation in autophagy suppression,tumor progression,and tumor chemoresistance[J].Cell,2013,154(6):1269-1284.
[27] LOTSBERG M L,WNUK-LIPINSKA K,TERRY S,et al.AXL targeting abrogates autophagic flux and induces immunogenic cell death in drug-resistant cancer cells[J].J Thorac Oncol,2020,15(6):973-999.
[28] TO K K W,WU W K K,LOONG H H F.PPARgamma agonists sensitize PTEN-deficient resistant lung cancer cells to EGFR tyrosine kinase inhibitors by inducing autophagy[J].Eur J Pharmacol,2018,823(4):19-26.
[29] HU X,SHI S,WANG H,et al.Blocking autophagy improves the anti-tumor activity of afatinib in lung adenocarcinoma with activating EGFR mutations in vitro and in vivo[J].Sci Rep,2017,7(1):4559.
[30] CHEN Z,HUANG C,YANG Y L,et al.Inhibition of the STAT3 signaling pathway is involved in the antitumor activity of cepharanthine in SaOS2 cells[J].Acta Pharmacol Sin,2012,33(1):101-108.
[31] OKAMOTO M,ONO M,BABA M.Suppression of cytokine production and neural cell death by the anti-inflammatory alkaloid cepharanthine:a potential agent against HIV-1 encephalopathy[J].Biochem Pharmacol,2001,62(6):747-753.
[32] ZHOU Y B,WANG Y F,ZHANG Y,et al.In vitro activity of cepharanthine hydrochloride against clinical wild-type and lamivudine-resistant hepatitis B virus isolates[J].Eur J Pharmacol,2012,683(1-3):10-15.
[33] LIU G,WU D,LIANG X,et al.Mechanisms and in vitro effects of cepharanthine hydrochloride:classification analysis of the drug-induced differentially-expressed genes of human nasopharyngeal carcinoma cells[J].Oncol Rep,2015,34(4):2002-2010.
[34] UTHAISAR K,SEUBWAI W,SRIKOON P,et al.Cepharanthine suppresses metastatic potential of human cholangiocarcinoma cell lines[J].Asian Pac J Cancer Prev,2012,13(Suppl):149-154.
[35] HARADA K,FERDOUS T,ITASHIKI Y,et al.Effects of cepharanthine alone and in combination with fluoropyrimidine anticancer agent,S-1,on tumor growth of human oral squamous cell carcinoma xenografts in nude mice[J].Anticancer Res,2009,29(4):1263-1270.
[36] TANG Z H,CAO W X,GUO X,et al.Identification of a novel autophagic inhibitor cepharanthine to enhance the anti-cancer property of dacomitinib in non-small cell lung cancer[J].Cancer Lett,2018,412(5):1-9.
[37] LI Y Y,LAM S K,MAK J C,et al.Erlotinib-induced autophagy in epidermal growth factor receptor mutated non-small cell lung cancer[J].Lung Cancer,2013,81(3):354-361.
[38] WHITESELL L,LINDQUIST S L.HSP90 and the chaperoning of cancer[J].Nat Rev Cancer,2005,5(10):761-772.
[39] HAN J,GOLDSTEIN L A,HOU W,et al.HSP90 inhibition targets autophagy and induces a CASP9-dependent resistance mechanism in NSCLC[J].Autophagy,2018,14(6):958-971.
[40] LEE Y J,KIM N Y,SUH Y A,et al.Involvement of ROS in curcumin-induced autophagic cell death[J].Korean J Physiol Pharmacol,2011,15(1):1-7.
[41] KIM J Y,CHO T J,WOO B H,et al.Curcumin-induced autophagy contributes to the decreased survival of oral cancer cells[J].Arch Oral Biol,2012,57(8):1018-1025.
[42] ZHUANG W,LONG L,ZHENG B,et al.Curcumin promotes differentiation of glioma-initiating cells by inducing autophagy[J].Cancer Sci,2012,103(4):684-690.
[43] XIAO K,JIANG J,GUAN C,et al.Curcumin induces autophagy via activating the AMPK signaling pathway in lung adenocarcinoma cells[J].J Pharmacol Sci,2013,123(2):102-109.
[44] CHEN P,HUANG H P,WANG Y,et al.Curcumin overcome primary gefitinib resistance in non-small-cell lung cancer cells through inducing autophagy-related cell death[J].J Exp Clin Cancer Res,2019,38(1):254-271.
[45] CAO Q,YOU X,XU L,et al.PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy[J].Autophagy,2020,16(7):1236-1247.
[46] LEE T G,JEONG E H,KIM S Y,et al.The combination of irreversible EGFR TKIs and SAHA induces apoptosis and autophagy-mediated cell death to overcome acquired resistance in EGFR T790M-mutated lung cancer[J].Int J Cancer,2015,136(11):2717-2729. |
