Objective: To investigate the correlation between vascular endothelial growth factor(VEGF), vascular intercellular adhesion molecule-1(ICAM-1) and proliferative diabetic retinopathy and their combined diagnostic value.Methods: 153 cases of diabetic retinopathy diagnosed in our hospital from April 2017 to April 2020 were retrospectively studied. 72 patients with proliferative diabetic retinopathy were included in the observation group; 81 patients with non proliferative diabetic retinopathy were included in the control group. Flow cytometry was used to determine the type of vascular endothelial cells, and enzyme-linked immunosorbent assay was used to detect VEGF and ICAM-1. The difference and correlation between the two groups were compared, and ROC curve was used to determine the combined diagnostic efficiency.Results: The content of circulating endothelial cells(CEC) in the observation group was significantly higher than that in the control group(P<0.05); the content of circulating progenitor cells(CPC) in the observation group was significantly lower than that in the control group(P<0.05); the levels of VEGF and ICAM-1 in the observation group were significantly higher than those in the control group(P<0.05). There was a significantly positive correlation between VEGF and ICAM-1(r=0.732, P=0.011), there was a significantly positive correlation between VEGF and CEC(r=0.684, P=0.023, there was a significantly negative correlation between VEGF and CPC(r=-0.622, P=0.041). The area under the curve(AUC) of VEGF was 0.844, specificity was 85.32%, sensitivity was 82.16%; AUC of ICAM-1 was 0.821, specificity was 83.74%, sensitivity was 80.21%; AUC of joint diagnosis was 0.914, specificity was 88.92%, sensitivity was 92.25%.Conclusion: VEGF and ICAM-1 have a significant co-directional change relantionship with proliferative diabetic retinopathy, that is, VEGF and ICAM-1 increase with the disease, and have good joint diagnostic efficacy.
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