目的：评估急性高动力型心力衰竭（心衰）时不同的硝普钠使用策略对于症状控制和预后的影响。方法：将我院2015年至2017年收治的73例急性高动力型心衰患者，随机分为实验组及对照组，实验组给予初始负荷剂量（5 μg·kg^-1·min^-1）硝普钠，对照组给予小剂量（0.3 μg·kg^-1·min^-1）逐渐递增，首要终点为患者临床症状及体征改善，次要终点为患者再发心衰或死亡。结果：实验组的氧合恢复、症状恢复、血压稳定时间分别为（36.5±8.2）min、（42.6±7.9）min、（28.8±5.9）min，均短于对照组的（90.6±17.5）min、（106.3±22.6）min、（94.5±11.2）min （均P<0.001）；两组患者再住院率及死亡率差异无统计学意义（均P>0.05）。结论：急性高动力型心衰给予负荷剂量硝普钠有助于短期内控制心衰症状及体征，而对再发心衰及心血管死亡率无明显影响。

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