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sST2在急性心力衰竭诊断中的应用及对短期预后的评估价值
作者:张翥  范修才  陶亮亮 
单位:南通大学附属建湖医院 心内科, 江苏 盐城 224700
关键词:急性心力衰竭 可溶性生长刺激表达基因蛋白2 氨基末端脑钠肽前体 受试者工作特征曲线 诊断 预后 
分类号:R540.4
出版年·卷·期(页码):2021·49·第三期(317-320)
摘要:

目的:探讨血浆可溶性生长刺激表达基因蛋白2(sST2)水平在急性心力衰竭诊断中的应用及对患者短期预后的评估价值。方法:选取2016年9月至2017年11月间在我院心血管内科收治的78例初诊急性心力衰竭患者为观察组,同一时间段内因胸痛就诊而冠状动脉造影正常的患者60例为对照组,测定血浆sST2和氨基末端脑钠肽前体(NT-proBNP)水平,分析其对急性心力衰竭的诊断价值。再根据sST2水平将观察组分为高水平组(40例)和低水平组(38例),记录随访180 d内的主要不良心血管事件的发生情况,评估血浆sST2水平在急性心力衰竭短期临床预后中的价值。结果:观察组患者血浆sST2和NT-proBNP水平显著高于对照组,差异有统计学意义(P<0.001)。随访180 d发现高水平组不良心血管事件发生率明显高于低水平组,差异有统计学意义(P<0.001)。受试者工作特征(ROC)曲线分析显示,sST2和NT-proBNP水平两项联合检测的曲线下面积大于单项指标检测。Logistic回归分析显示sST2是影响AHF患者短期预后的独立危险预测因子(P<0.05)。结论:sST2可作为诊断急性心力衰竭的生物标志物,与NT-proBNP联合检测可提高对急性心力衰竭的诊断价值,同时血浆sST2水平对急性心力衰竭患者短期预后具有较高的临床评估价值。

参考文献:

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