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CRP、NEU、ESR对腰椎间隙感染的诊断评价
作者:徐阔  季娜  王婷 
单位:大连市第三人民医院 检验科, 辽宁 大连 116033
关键词:C反应蛋白 红细胞沉降率 中性粒细胞计数 腰椎间隙感染 
分类号:R681.5
出版年·卷·期(页码):2021·49·第一期(79-82)
摘要:

目的: 分析C反应蛋白(C-reactive protein,CRP)、中性粒细胞计数(neutrophil,NEU)、红细胞沉降率(erythrocyte sedimentation rate,ESR)对腰椎间隙感染的诊断价值。方法: 收集2013年1月1日至2019年3月1日60例腰椎间隙感染患者作为实验组,选择同时期的60例健康体检者作为对照组。分析两组患者CRP、NEU、ESR水平以及其在治疗过程中的变化。结果:实验组治疗前CRP、NEU、ESR水平明显高于对照组(P<0.05)。治疗3 d后CRP明显低于治疗前水平(P<0.05);治疗6 d后,NEU明显低于治疗前水平(P<0.05);ESR在治疗3 d和6 d后的水平与治疗前差异无统计学意义(P>0.05)。CRP、ESR、NEU的敏感度分别为95.8%、95.8%、79.2%,特异度分别为95.8%、91.7%、95.8%。3项指标联合检测的敏感度是100%,特异度是96.2%。结论: CRP、NEU、ESR可作为腰椎间隙感染的辅助诊断指标。诊断效能是3项指标联合检测>CRP>ESR>NEU。CRP在抗生素疗效评估过程中具有应用价值。CRP、NEU、ESR诊断腰椎间隙感染的最佳工作点分别是15.05 mg·L-1、6.2×109 L-1、14 mm·H-1

Objective: To analyze the value of lumbar intervertebral infection by C-reactive protein (CRP), neutrophil(NEU) and erythrocyte sedimentation rate(ESR) of diagnosis and treatment monitoring. Methods: Sixty patients with lumbar intervertebral infection during January 1, 2013 to March 1, 2019 were collected as the experiment group. The healthy cases in the same periods were collected as the control group. The levels of CRP, NEU, and ESR were analyzed during the treatment. Results: The levels of CRP, NEU and ESR before treatment were significantly higher than those of the control group (P<0.05). The CRP of the experiment group decreased significantly after 3 days' treatment (P<0.05). The NEU of the experiment group decreased significantly after 6 days' treatment (P<0.05). After treatment for 3 and 6 days, changes of ESR in experiment group were insignificant (P>0.05). The sensitivity and the specificity of CRP were 95.8% and 95.8%, the sensitivity and the specificity of ESR were 95.8% and 91.7%, the sensitivity and the specificity of NEU were 79.2% and 95.8%.When the 3 tests were used in combination, the sensitivity and the specificity were 100% and 96.2%. Conclusion: CRP,NEU and ESR can be taken as auxiliary diagnostic indexes of lumbar intervertebral space infection. The diagnostic efficacy is in the following descending order:the combined detection of three tests, CRP, ESR, NEU. CRP can play a key role in the assessment of curative effect on lumbar intervertebral space infection of antibiotics. The critical values of CRP, NEU and ESR were 15.05 mg·L-1, 6.2×109 L-1 and 14 mm·H-1respectively.

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