Objective: To investigate the relationship between homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride-glucose (TyG) index and chronic kidney disease (CKD).Methods: Participants in the 2009 Chinese Health and Nutrition Surveywere selected as study samples. Logistic regression analysis was used to analyze the risk of HOMA-IR and TyG index in predicting CKD, and receiver operating characteristic(ROC) curve analysis was used to evaluate the efficacy of HOMA-IR and TyG index in diagnosing CKD. Results: HOMA-IR, TyG index, body fat index (visceral fat index, lipid accumulation index) and inflammatory index (high sensitivity C-reactive protein) in CKD group were significantly higher than those in non-CKD group(P<0.01).The prevalence of CKD increased with the level of HOMA-IR, TyG index. After adjusting for age, sex, smoking, alcohol consumption, blood pressure, cholesterol, and diabetes, the risk of CKD increased 1.849,1.844-fold in the 4th quartile of HOMA-IR and TyG index compared with the first quartile, respectively(P<0.05). The area under the ROC curve AUC[95% confidence interval (CI)] of HOMA-IR for diagnosing CKD was 0.592 (0.581-0.603), the cut off value was 2.831, the sensitivity was 54.14%, and the specificity was 62.17%. The area under the ROC curve AUC (95% CI) of TyG index for diagnosing CKD was 0.607 (0.597-0.618), the cut off value was 3.62, the sensitivity was 80.25%, and the specificity was 38.06%.Conclusion: Insulin resistance is associated with CKD. HOMA-IR and TyG index are independent influencing factors of CKD, which can predict the risk of CKD.
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