目的： 探讨经鼻高流量氧疗联合肺康复训练对慢性阻塞性肺疾病（COPD）合并呼吸衰竭患者肺功能、血气分析指标、生活质量的影响。方法： 选择我科2017年1月至2019年3月间收治的COPD合并呼吸衰竭患者60例。采用随机数字表法结合个人意愿将其分为对照组和观察组，各30例。对照组给予持续经鼻低流量氧吸入治疗，观察组给予经鼻高流量氧疗联合肺康复训练治疗。比较两组患者临床症状缓解时间及住院时间，干预12周后用力肺活量（FVC）、第1秒用力呼气量（FEV1）、FEV1/FVC、血氧饱和度（SaO₂）、血氧分压（PaO₂）、二氧化碳分压（PaCO₂）、生存质量改善情况。结果： 观察组患者干预后咳嗽、咳痰、气促等症状缓解时间及住院时间均短于对照组（P<0.05）；两组干预前肺功能指标、动脉血气分析指标及StGeorge's呼吸疾病问卷评估表（SGRQ）评分比较，差异均无统计学意义（均P>0.05）；干预后观察组FVC、FEV1、FEV1/FVC、6 min步行试验（6MWT）、SaO₂、PaO₂等指标均升高，差值均大于对照组（均P<0.05），PaCO₂、SGRQ评分均降低，差值均大于对照组（均P<0.05）。结论： 经鼻高流量氧疗联合肺康复训练可加速COPD合并呼吸衰竭患者临床症状缓解，缩短住院时间，提高肺功能，改善血气分析指标及生存质量，临床干预效果显著，值得进行应用和推广。

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