慢性阻塞性肺疾病（COPD）是由多种因素共同导致的气道和全身的慢性炎症性疾病，造成沉重的社会和经济负担。脂肪细胞型脂肪酸结合蛋白（A-FABP/FABP4）作为脂肪酸结合蛋白家族的重要一员，主要分布于脂肪细胞和巨噬细胞之中，在参与炎症反应、脂肪酸转运等方面发挥重要作用。随着脂质代谢研究的不断深入，FABP4逐渐成为国内外研究的热点。近年来研究发现其与COPD的发生、发展关系紧密，现通过对FABP4与COPD关系的研究进展进行综述，以期为COPD的防治研究提供新的思路。

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