吉西他滨膀胱灌注治疗对经尿道膀胱肿瘤电切术后膀胱痉挛的影响-现代医学

吉西他滨膀胱灌注治疗对经尿道膀胱肿瘤电切术后膀胱痉挛的影响

单位：泰州市第二人民医院泌尿外科, 江苏泰州 225300

分类号：R737.14

出版年·卷·期（页码）：2020·48·第十期（1298-1301）

摘要：

目的：探讨和分析吉西他滨膀胱灌注治疗对经尿道膀胱肿瘤电切术（TURBT）后膀胱痉挛的影响。方法：选取2016年1月至2019年12月我院收治的78例膀胱肿瘤患者为研究对象，采用随机数字表法将其分为对照组（39例）和观察组（39例）。对照组给予TURBT治疗，观察组在对照组的基础上联合吉西他滨膀胱灌注治疗。采用视觉模拟评分（VAS）及膀胱痉挛症状评分（BSSS）评估两组患者的疼痛程度及膀胱痉挛症状严重程度。结果：观察组术后1、3、5、7 d膀胱痉挛的平均发生频次少于对照组，且膀胱痉挛的持续时间也短于对照组，差异均有统计学意义（P<0.05）；观察组术后6、12、24 h的VAS评分低于对照组，差异均有统计学意义（P<0.05）；观察组膀胱痉挛症状严重程度显著轻于对照组，差异有统计学意义（P<0.05）。结论：吉西他滨膀胱灌注治疗能缓解患者TURBT后膀胱痉挛的疼痛，并缩短痉挛时间，减轻患者膀胱痉挛症状。

Objective: To investigate and analyze the effect of gemcitabine bladder perfusion therapy on patients with bladder spasm after transurethral resection of bladder tumor. Methods: From January 2016 to December 2019, a total of 78 patients with bladder tumor who underwent transurethral resection in our hospital, were selected as the study subjects. Patients were divided into control group(39 cases) and observation group(39 cases) randomly. The control group was treated with transurethral resection of tumor, while the observation group was treated with transurethral resection followed by Gemcitabine bladder perfusion. Visual Analogue Scale(VAS) and Bladder Spasm Symptom Score(BSSS) were used to evaluate the degree of pain and the severity of bladder spasm. Results: The frequency of bladder spasm in the observation group was significantly lower than that in the control group on day 1, 3, 5 and 7 after surgery, and the duration of bladder spasm was significantly shorter than that in the control group(P<0.05);At 6 h, 12 h and 24 h after surgery, the VAS score of the observation group was significantly lower than that of control group(P<0.05);BSSS evaluation showed that both groups had different degrees of bladder spasm after surgery, but the severity of bladder spasm in the observation group was significantly lower than that in the control group(P< 0.05). Conclusion: Gemcitabine bladder perfusion therapy can relieve the pain brought by bladder spasm after transurethral resection, shorten the duration of spasm, and alleviate the symptoms of bladder spasm.

参考文献：

[1] 郑龙宝,郑美英,仇让学,等.经尿道电切联合吉西他滨膀胱灌注治疗膀胱癌临床疗效观察[J].临床合理用药杂志,2019,12(13):17-18.
[2] 霍倩,段靳岚,马玉梅,等.吉西他滨与吡柔比星行膀胱灌注预防膀胱肿瘤复发有效性及安全性的Meta分析[J].国际泌尿系统杂志,2018,38(6):912-916.
[3] 王磊,胡常华,赵瑜,等.经尿道膀胱肿瘤电切术联合吉西他滨膀胱灌注治疗浅表性膀胱癌的临床效果分析[J].中国基层医药,2018,25(17):2180-2183.
[4] 陈梅霞,陈萍萍.经尿道膀胱肿瘤电切术后盐酸吉西他滨膀胱灌注的护理对策[J].当代护士(上旬刊),2017(3):67-69.
[5] 王晓卫.Orem自护理论在膀胱肿瘤电切术后患者护理中的应用[J].现代医学,2017,45(5):751-753.
[6] 刘菲,刘萍,马月仙.穴位按摩联合温水足浴对前列腺电切术后膀胱痉挛的效果观察[J].现代医学,2017,45(4):593-597.
[7] 张国平,雷弋,王岭,等.吉西他滨膀胱灌注治疗非肌层浸润性膀胱癌的疗效及安全性分析[J].四川医学,2018,39(11):1246-1249.
[8] 刘安,张建斌.即刻灌注吉西他滨对非肌层浸润性膀胱癌术后预后的影响[J].解放军医药杂志,2018,30(10):31-33,38.
[9] 周凯.经尿道电切术联合吉西他滨灌注治疗膀胱癌的临床分析[J].吉林医学,2018,39(7):1309-1310.
[10] 张婵娟,张秀琳,孙文东,等.经皮电神经刺激脚底对围手术期膀胱痉挛的预防和治疗效果[J].中华物理医学与康复杂志,2017,39(1):64-66.
[11] 王惠良,周晓华,吴玉娟,等.集束化护理在经尿道前列腺电切术后膀胱痉挛患者中的应用效果[J].中华现代护理杂志,2018,24(16):1888-1891.
[12] 陈连华,张燕婷.经尿道前列腺电切术后膀胱痉挛的护理方法及效果分析[J].泰山医学院学报,2019,40(6):459-460.
[13] 郭瑞平.经尿道前列腺等离子电切术后冲洗液温度与膀胱痉挛的关系分析[J].临床合理用药杂志,2017,10(35):146-147.
[14] 韩保健,黄熠,张元霞,等.索利那新治疗经尿道前列腺切除术后膀胱痉挛临床效果的Meta分析[J].中国基层医药,2017,24(13):2038-2042,插3,插5.
[15] 王海琳,郭乔雪.肝素等药物膀胱灌注在前列腺电切术患者快速康复中的应用[J].国际医药卫生导报,2019,25(5):764-767.
[16] 黄鹤.护理干预措施应用于经尿道膀胱肿瘤电切术后膀胱痉挛患者的疗效观察[J].医学理论与实践,2018,31(14):2176-2177.
[17] 高占峰,王伟,于广海.索利那新预防前列腺癌根治术后膀胱痉挛的疗效分析[J].中国医师进修杂志,2017,40(5):403-406.

服务与反馈：

【文章下载】【发表评论】【查看评论】【加入收藏】

提示：您还未登录，请登录！点此登录