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吉西他滨膀胱灌注治疗对经尿道膀胱肿瘤电切术后膀胱痉挛的影响
作者:单勇  徐汉军  刘仁杰 
单位:泰州市第二人民医院 泌尿外科, 江苏 泰州 225300
关键词:经尿道膀胱肿瘤电切术 吉西他滨 膀胱灌注 膀胱痉挛 
分类号:R737.14
出版年·卷·期(页码):2020·48·第十期(1298-1301)
摘要:

目的:探讨和分析吉西他滨膀胱灌注治疗对经尿道膀胱肿瘤电切术(TURBT)后膀胱痉挛的影响。方法:选取2016年1月至2019年12月我院收治的78例膀胱肿瘤患者为研究对象,采用随机数字表法将其分为对照组(39例)和观察组(39例)。对照组给予TURBT治疗,观察组在对照组的基础上联合吉西他滨膀胱灌注治疗。采用视觉模拟评分(VAS)及膀胱痉挛症状评分(BSSS)评估两组患者的疼痛程度及膀胱痉挛症状严重程度。结果:观察组术后1、3、5、7 d膀胱痉挛的平均发生频次少于对照组,且膀胱痉挛的持续时间也短于对照组,差异均有统计学意义(P<0.05);观察组术后6、12、24 h的VAS评分低于对照组,差异均有统计学意义(P<0.05);观察组膀胱痉挛症状严重程度显著轻于对照组,差异有统计学意义(P<0.05)。结论:吉西他滨膀胱灌注治疗能缓解患者TURBT后膀胱痉挛的疼痛,并缩短痉挛时间,减轻患者膀胱痉挛症状。

Objective: To investigate and analyze the effect of gemcitabine bladder perfusion therapy on patients with bladder spasm after transurethral resection of bladder tumor. Methods: From January 2016 to December 2019, a total of 78 patients with bladder tumor who underwent transurethral resection in our hospital, were selected as the study subjects. Patients were divided into control group(39 cases) and observation group(39 cases) randomly. The control group was treated with transurethral resection of tumor, while the observation group was treated with transurethral resection followed by Gemcitabine bladder perfusion. Visual Analogue Scale(VAS) and Bladder Spasm Symptom Score(BSSS) were used to evaluate the degree of pain and the severity of bladder spasm. Results: The frequency of bladder spasm in the observation group was significantly lower than that in the control group on day 1, 3, 5 and 7 after surgery, and the duration of bladder spasm was significantly shorter than that in the control group(P<0.05);At 6 h, 12 h and 24 h after surgery, the VAS score of the observation group was significantly lower than that of control group(P<0.05);BSSS evaluation showed that both groups had different degrees of bladder spasm after surgery, but the severity of bladder spasm in the observation group was significantly lower than that in the control group(P< 0.05). Conclusion: Gemcitabine bladder perfusion therapy can relieve the pain brought by bladder spasm after transurethral resection, shorten the duration of spasm, and alleviate the symptoms of bladder spasm.

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