目的：探讨血清血栓调节蛋白（TM）、类血管生成素6（Angptl6）和β-痕迹蛋白（BTP）对妊娠期高血压疾病的诊断价值。方法：选取30例妊娠期高血压患者为妊娠期高血压组，30例子痫前期患者为子痫前期组，同时选取30例正常妊娠志愿者为正常妊娠组，检测3组患者血清中TM、Angptl6和BTP的表达量。用受试者工作特征（ROC）曲线的曲线下面积（AUC）分析TM、Angptl6和BTP检测在妊娠期高血压疾病中的诊断意义。结果：妊娠期高血压组TM、Angptl6和BTP的表达量均明显高于正常妊娠组（P<0.05），但均低于子痫前期组（P<0.05）。TM、Angptl6和BTP诊断妊娠期高血压的灵敏度分别为90.12%、80.32%和83.17%，特异度分别为76.34%、83.33%和83.33%。TM、Angptl6和BTP鉴别诊断妊娠期高血压及子痫前期的灵敏度分别为83.33%、90.29%和82.98%；特异度分别为86.67%、80.05%和83.29%。结论：血清TM、Angptl6和BTP的表达量检测可作为诊断妊娠期高血压疾病的潜在标志物。

[1] 王玉双,文亚南,司亚茹.复方丹参注射液治疗重度妊娠期高血压疾病的临床研究[J].中国中西医结合杂志,2017,37(11):1400-1402.
[2] 李红荣.eNOS、EPO、TNF-α基因多态性与青海省汉族妊娠高血压疾病相关性研究[D].西宁:青海大学,2017.
[3] 侯艳萍,王丽.妊娠期糖尿病患者孕期体质量指数、血清游离脂肪酸与胰岛素抵抗之间的关系[J].中国妇幼保健,2018,33(3):518-520.
[4] 梁燕,严久琼,徐明娟.交感神经活动与妊娠期高血压疾病[J].第二军医大学学报,2014,35(11):1254-1257.
[5] MÄNNISTÖ T,MENDOLA P,VÄÄRÄSMÄKI M,et al.Elevated blood pressure in pregnancy and subsequent chronic disease risk[J].Circulation,2013,127(6):681-690.
[6] VALDIVIEZO C,GAROVIC V D,OUYANG P.Preeclampsia and hypertensive disease in pregnancy:their contributions to cardiovascular risk[J].Clin Cardiol,2012,35(3):160-165.
[7] NADAR S K,AL Y E,BLANN A D,et al.Thrombomodulin,von Willebrand factor and E-selectin as plasma markers of endothelial damage/dysfunction and activation in pregnancy induced hypertension[J].Thromb Res,2004,113(2):123-128.
[8] DUAN B,ZHANG L,DING X,et al.Serum beta-trace protein as a novel predictor of pregnancy-induced hypertension[J].J Clin Hypertens,2016,18(10):1022-1026.
[9] TUURI A L,JAUHIAINEN M S,EHNHOLM C P,et al.Elevated serum angiopoietin-like protein 6 in women with subsequent pregnancy-induced hypertension:a preliminary study[J].Hypertens Pregnancy,2013,32(3):203-213.
[10] 郭艳.影响妊娠高血压疾病发病相关因素临床分析[J].系统医学,2018,3(8):33-35.
[11] 赵明,李光辉.妊娠20周前体重增长与妊娠期高血压关系的研究[J].中国妇幼健康研究,2016,27(9):1050-1051.
[12] 邹璐,李文蕾,贾晓婕.孕早期血清人绒毛膜促性腺激素β与血脂预测妊娠期高血压疾病的价值[J].现代医学,2015,43(6):768-771.
[13] 陆菲菲,宋天然,王玢,等.输卵管预处理对行体外受精-胚胎移植患者卵巢反应性及妊娠结局的影响[J].现代医学,2017,45(1):97-99.
[14] RUNDELL K,PANCHAL B.Preterm labor:prevention and management[J].Am Fam Physician,2017,95(6):366-372.
[15] 田兴华,王梦佳,潘登科.血管内皮特异性表达人血栓调节蛋白转基因猪的研究[J].农业生物技术学报,2018,26(4):556-563.
[16] 弭雪.出凝血分子标志物在弥散性血管内凝血中的动态变化及意义[D].济南:山东大学,2017.
[17] MA S Q,BAI C M.Study on thrombomodulin and plasminogen activator inhibitor type 1 in patients of pregnancy induced hypertention[J].Chin J Obstet Gyneco,1999,34(12):712-714.
[18] BOFFA M C,VALSECCHI L,FAUSTO A,et al.Predictive value of plasma thrombomodulin in preeclampsia and gestational hypertension[J].Thromb Haemost,1998,79(6):1092-1095.
[19] 薛茜文,黄鑫,郝翠芳.血管生成素样蛋白基因与卵泡发育及脂类代谢的研究进展[J].生殖医学杂志,2014,23(5):421-425.
[20] 马云,付香斌,李芬,等.哺乳动物类血管生长因子基因(ANGPTL)的研究进展[J].信阳师范学院学报(自然科学版),2008,21(3):474-477.
[21] WANG W,LI X,JI D.Molecular mechanism of the effect of angiopoietin-like protein 8 on the proliferation,invasion and migration of placental trophoblasts in preeclampsia[J].Exp Ther Med,2020,19(6):3461-3468.
[22] KHOSRAVI N,ASGARI M,KHALESSI N,et al.Serum beta-trace protein for assessment of kidney function in neonates[J].Iran J Kidney Dis,2018,12(1):11-13.
[23] ARRER E,MECO C,OBERASCHER G,et al.Beta-trace protein as a marker for cerebrospinal fluid rhinorrhea[J].Clin Chem,2002,48(1):939-941.
[24] HIRAWA N,UEHARA Y,YAMAKADO M,et al.Lipocalin-type prostaglandin d synthase in essential hypertension[J].Hypertension,2002,39(2):449-454.