极速脉搏波技术定量评价慢性肾脏病患者颈动脉弹性的临床研究-现代医学

极速脉搏波技术定量评价慢性肾脏病患者颈动脉弹性的临床研究

单位：南京中医药大学附属医院超声医学科, 江苏南京 210029

分类号：R445.1;R692

出版年·卷·期（页码）：2020·48·第十期（1273-1275）

摘要：

目的：探讨极速脉搏波技术（ufPWV）在定量评价慢性肾脏病患者颈动脉弹性中的应用价值。方法：选择经临床确诊的41例慢性肾脏病（CKD）患者为实验组，同期江苏省中医院体检中心体检的非慢性肾脏病（nCKD）者97例为对照组。利用ufPWV技术分别检测脉搏波指标：收缩早期脉搏波速度（BS）和收缩末期脉搏波速度（ES）。获取每例患者的双侧颈总动脉数据，根据血脂水平将每组患者分为高脂血症亚组和血脂正常亚组，比较各亚组的BS及ES数据。结果：实验组ES显著高于对照组（P<0.05），两组BS比较差异无统计学意义（P>0.05）。实验组高脂血症亚组和血脂正常亚组的ES及BS比较差异均无统计学意义（均P>0.05）。对照组高脂血症亚组的ES显著高于血脂正常亚组（P<0.05），两亚组间的BS比较差异无统计学意义（P>0.05）。结论：CKD患者的颈动脉弹性较nCKD者减低，ufPWV技术可快速测量CKD患者颈动脉的ES，是一种简单评价CKD患者血管弹性功能的新方法。

Objective: To explore the ultrafast pulse wave velocity(ufPWV) technique on the quantitative evaluation of carotid artery elasticity in patients with chronic kidney disease(CKD).Methods: 41 CKD patients were selected as the experimental group and 97 non-CKD(nCKD)individual from physical examination center were selected as control group. The ufPWV technique was used to detect the pulse wave index, including beginning of systole(BS) velocity and end of systole(ES) velocity. Every individual had two BS data and two ES data due to the left and right side. Each group was divided into hyperlipidemia subgroup and normal lipid subgroup according to hematic fat.Results: ES in experiment group was higher than that in control group(P<0.05). However, the BS had no significant difference between the two groups(P>0.05). In experimental group, there were no significant difference in ES and BS between the hyperlipidemia subgroup and normal lipid subgroup(P>0.05). In control group, ES of hyperlipidemia subgroup was significantly higher than that of normal lipid subgroup,but there was no significant difference in BS between the two subgroups(P<0.05).Conclusion: The carotid artery elasticity in CKD patients is poor than that in nCKD individual.The ufPWV technique can quickly measure the ES of carotid artery in CKD patients. It provides a novel and convenient method to evaluate vascular elasticity in patients with CKD.

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