Objective: To observe the clinical efficacy of high intensity focused ultrasound(HIFU) in treating uterine fibroids and its effects on patients' ovarian and immune functions.Methods: 132 patients with uterine fibroids were divided into HIFU group(60 cases),myomectomy group(39 cases) and hysterectomy group(33 cases) according to different surgical procedures. The hemoglobin concentrations, menstrual cycle, endometrial thickness, ovarian and immune function before operation and 6 months after operation were measured.Results: Compared with the preoperative results, the hemoglobin concentrations in each group were increased significantly at 6 months after operation, menstrual cycle of HIFU group and myomectomy group were shortened significantly, endometriumofmyomectomy group was thinner significantly(P<0.05), endometriumof HIFU group was significantly thicker than that of myomectomy group(P<0.05), the follicle-stimulating hormone(FSH) and luteinizing hormone(LH) at 6 months after operation in hysterectomy group were significantly higher and estradiol(E2) was significantly lower, FSH and LH in hysterectomy group were significantly different from those in HIFU group and fibroid-elimination group(P<0.05).At 6 months after operation, the immune function indicators in HIFU group were significantly higher than that in myomectomy group and hysterectomy group(P<0.05). Conclusion: HIFU has no significant effect on ovarian and immune function in patients with uterine fibroids, and HIFU can be used as the preferred treatment for uterine fibroids under the premise of the surgical indications.
 BULUN S E.Uterine fibroids[J].N Engl J Med,2013,369(14):1344-1355.
 SEON S G,SIHYUM C,MAN K Y,et al.Current medical treatment of uterine fibroids[J].Obstet Gynecol Sci,2018,61(2):192-201.
 ZHANG L,ZHANG W,ORSI F,et al.Ultrasound-guided high intensity focused ultrasound for the treatment of gynaecological diseases:a review of safety and eficacy[J].Int J Hyperthermia,2015,31(3):280-284.
 QIN J,CHEN J Y,ZHAO W P,et al.Outcome of unintended regnancy after ultrasound-guided high-intensity focused ultrasound ablation of uterine fibroids[J].Int J Gynaecol Obstet,2012,117(3):273-277.
 MOORMAN P G,MYERS E R,SCHILDKRAUT J M,et al.Effect of hysterectomy with ovarian preseravtion on ovarian function[J].Obstet Gynecol,2011,118(6):1271-1279.
 WANG X,QIN J,CHEN J,et al.The efect of high-intensity focused ultrasound treatment on immune function in patients with uterine fibroids[J].Int J Hyperthermia,2013,29(3):225-233.
 BIJGAART R J E V D,EIKELENBOOM D C,HOOGENBOOM M,et al.Thermal and mechanical high-intensity focused ultrasound:perspectives on tumor ablation,immune effects and combination strategies[J].Cancer Immunol Immunother,2017,66(2):247-258.