强直性脊柱炎是病因不明的免疫介导的脊柱关节病，严重影响患者生活质量，甚至导致畸形，但其诊疗过程中存在实验室指标特异性不高及缺乏个体化治疗的缺陷。代谢组学作为新兴研究领域，可通过对患者血液、尿液、粪便及其他组织的代谢成分分析，协助揭示强直性脊柱炎的发病机制、发掘新的生物标志物、分析中药及中成药的提取物成分，从而在本病的发病机制、早期诊断、病情评估及个体化治疗等方面发挥重要作用。本文作者对代谢组学在强直性背柱炎病研究中的应用进行总结和综述。

[1] WANG W,YANG G,ZHANG J,et al.Plasma,urine and ligament tissue metabolite profiling reveals potential biomarkers of ankylosing spondylitis using NMR-based metabolic profiles[J].Arthritis Res Ther,2016,18(1):244.
[2] GAO P,LU C,ZHANG F,et al.Integrated GC-MS and LC-MS plasma metabonomics analysis of ankylosing spondylitis[J].Analyst,2008,133(9):1214-1220.
[3] CHEN R,HAN S,DONG D,et al.Serum fatty acid profiles and potential biomarkers of ankylosing spondylitis determined by gas chromatography-mass spectrometry and multivariate statistical analysis[J].Biomed Chromatogr,2015,29(4):604-611.
[4] HE Z,WANG M,LI H,et al.GC-MS-based fecal metabolomics reveals gender-attributed fecal signatures in ankylosing spondylitis[J].Sci Rep,2019,9(1):3872.
[5] FISCHER R,TRUDGIAN D,WRIGHT C,et al.Discovery of candidate serum proteomic and metabolomic biomarkers in ankylosing spondylitis[J].Mol Cell Proteomics,2012,11(2):M111.013904.
[6] TURINA M C,YEREMENKO N,GAALEN F,et al.Serum infflammatory biomarkers fail to identify early axial spondyloarthritis:results from the spondyloarthritis caught early (SPACE) cohort[J].RMD Open,2017,3(1):e000319.
[7] MAKSYMOWYCH W P.An update on biomarker discovery and use in axial spondyloarthritis[J].Expert Rev Mol Diagn,2017,17(11):965-974.
[8] FROMMER K W,SCHAFFLER A,REHART S,et al.Free fatty acids:potential proinfflammatory mediators in rheumatic diseases[J].Ann Rheum Dis,2015,74(1):303-310.
[9] GAO D,WANG B G,HUO Z,et al.Analysis of chemical constituents in an herbal formula Jitongning Tablet[J].J Pharm Biomed Anal,2017,140:301-312.
[10] OMER E,ELSHAMY A,NASSAR M,et al.Plantago squarrosa murray extracts inhibit the growth of some bacterial triggers of autoimmune diseases:GC-MS analysis of an inhibitory extract[J].Inflammopharmacology,2019,27(2):373-385.
[11] WINNETT V,SIRDAARTA J,WHITE A,et al.Inhibition of klebsiella pneumoniae growth by selected Australian plants:natural approaches for the prevention and management of ankylosing spondylitis[J].Inflammopharmacology,2017,25(2):223-235.
[12] SUN Z,QIU G,ZHAO Y.Application and research advances of metabolomics in the field of orthopedics[J].Chin J Surg,2015,53(6):476-480.