组蛋白赖氨酸特异性去甲基化酶1（LSD1）是一种去甲基酶，其功能依赖黄素腺嘌呤二核苷，能特异性催化组蛋白赖氨酸H3第4位和第9位的去一甲基、二甲基反应（H3K4me、H3K4me2、H3K9me、H3K9me2），调控靶基因的表达。正常组织中有LSD1的表达，多种肿瘤组织中也易表达，并且与肿瘤的发生、增殖、侵袭转移过程密切相关。LSD1在细胞内能与多种蛋白结合形成复合物，各司其职，共同调控靶基因，将这些蛋白称为LSD1相互作用蛋白。本文作者就LSD1相互作用蛋白的研究成果作一综述。

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