Objective: To investigate the expression levels of silence information regulator 1(SIRT1) and silence information regulator 3(SIRT3) in placental tissues of pre-eclampsia(PE) women and their correlation with maternal prognosis. Methods: One hundred and twenty-two cases of pregnant women treated in Hubei maternal and child health hospital from March 2018 to March 2019 were selected. Of them, there were 62 cases in case group, which was subdivided into mild case group(30 cases) and severe case group(32 cases) according to clinical severity, and into case group A(preterm preeclampsia without labor(PE), 36 cases), and case group B(full-term non-labor PE, 26 cases) according to gestational age. There were 60 cases in the control group, which was divided into control group A(preterm labor without labor, 30 cases) and control group B(full-term labor without labor, 30 cases) according to gestational age. The expression levels of SIRT1 and SIRT3 in placenta of pregnant women were quantitatively detected by immunohistochemistry, and the correlation between expression levels of SIRT1, SIRT3 and prognosis of pregnant women was analyzed.Results: The systolic and diastolic blood pressures of pregnant women in case group were significantly higher than those in the control group(P<0.05), but there was no significant difference between gestational age and chronic hypertension(P>0.05). Pregnancy frequency, parity, neonatal weight and the proportion of newborns less than the time of gestational age in case group A were not significantly different from those in the control group A(P>0.05), while the pregnancy frequency, parity and neonatal weight in case group B were significantly lower than those in the control group B(P<0.05), and the proportion of infants less than the time of gestational age was significantly higher than that in control group B(P<0.05). The protein expression score and positive rate of SIRT1, SIRT3 in case group were significantly lower than those in the control group(P<0.05). The protein expression score and positive rate of SIRT1 and SIRT3 in severe case group were significantly lower than those in mild case group(P<0.05). The severity of pre-eclampsia was negatively correlated with expression levels of SIRT1 and SIRT3 proteins(P<0.05). The incidence of postpartum hemorrhage, placental abruption, DIC, heart failure and total adverse events in SIRT1 and SIRT3 high expression groups were lower than those in SIRT1 and SIRT3 low expression groups(P<0.05).Conclusion: The expression of SIRT1 and SIRT3 in placenta of pre-eclampsia pregnant women are decreased, and there is more poor prognosis in pre-eclampsia pregnant women with low expression of SIRT1 or SIRT3, which can be used as biomarkers to judge the severity and prognosis of pre-eclampsia pregnant women.
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