Objective: To study the clinical efficacy of tirofiban combined with aspirin and clopidogrel on scores of Daily Living Ability Scale(ADL) and National Institute of Health Stroke Scale (NIHSS) in patients with acute progressive cerebral infarction.Methods: 90 patients with acute progressive cerebral infarction admitted to our hospital from July 2018 to July 2019 were randomly divided into observation group andcontrol group(45 cases). The control group was treated with aspirin and clopidogrel, on top of which the observation group was given tirofiban. The clinical efficacy, ADL, NIHSS and adverse reactions between the two groups were statistically analyzed.Results: The total effective rate was 88.89% in the observation group, 71.11% in the control group (P<0.05). In the observation group, the NIHSS were lower than those during the time of 24 h, 72 h, 7 d and 14d,respectively (P<0.05) and meanwhile, the differentials of ADL between post treatment and prior treatment were high than those in the control group (P<0.05). The incidence of adverse reactions was 13.85% in the observation group, 7.69% in the control group(P > 0.05).Conclusion: Tirofiban combined with aspirin and clopidogrel has a curative effect in acute progressive cerebral infarction, improving the brain microcirculation blood flow and nerve function, enhancing life quality of patients, and ensuring the safety of the therapy. |
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