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老年冠心病患者血清CTRP6水平与冠状动脉病变程度的相关性研究
作者:魏欣辉1  李绪锋2 
单位:1. 宝鸡市人民医院 老年病科, 陕西 宝鸡 721000;
2. 凤翔县医院 内五科, 陕西 凤翔 721400
关键词:补体C1q/肿瘤坏死因子相关蛋白6 Gensini评分 冠状动脉粥样硬化性心脏病 老年 
分类号:R541.4
出版年·卷·期(页码):2020·39·第七期(841-844)
摘要:

目的:观察老年冠心病(CHD)患者血清补体C1q/肿瘤坏死因子相关蛋白6(CTRP6)水平变化及其与冠状动脉病变程度的关系。方法:选择2015年1月至2017年7月在我院接受冠状动脉造影(CAG)检查的495 例老年患者纳入研究,包括CHD组361 例和CAG阴性(对照)组134 例。采用酶联免疫吸附法(ELISA)检测血清 CTRP6水平,比较CHD组和对照组血清CTRP6水平,观察血清CTRP6水平与老年CHD患者冠状动脉病变严重程度的关系。结果:CHD组和对照组血清CTRP6水平分别为(22.81±7.55) ng·ml-1和(48.65±8.38) ng·ml-1,CHD组低于对照组,差异具有统计学意义(t=32.82,P<0.001)。Spearman直线相关分析示血清CTRP6水平与冠状动脉病变数目及Gensini评分均呈负相关(r=-0.25,P<0.001;r=-0.44,P<0.001)。多元线性回归分析示血清CTRP6水平升高是老年CHD患者Gensini评分重度病变的独立保护因素(OR=0.66;95%CI 0.45~0.96;P=0.002)。受试者工作特征(ROC)曲线分析示血清CTRP6预测老年CHD患者Gensini评分重度病变的曲线下面积为0.84。结论:老年CHD患者血清CTRP6水平与其冠状动脉病变程度呈负相关,有望成为老年CHD患者早期诊断及病变严重程度评估的新指标。

参考文献:

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