Objective:To compare the clinical effects of open radical gastrectomy for gastric-jejunal side-to-side anastomosis and end-to-side anastomosis in the treatment of gastric cancer. Methods:To review the clinical data of 175 patients who underwent two surgical procedures from January 2013 to December 2019 in Southeast University Affiliated Zhongda Hospital, including 103 cases in end-to-side anastomosis group and 72 cases in side-to-side anastomosis group. The operation time, bleeding volume, postoperative complication rate, hospital stay, and total cost of the two groups were compared.Results: All patients successfully completed radical distal gastrectomy(D2 lymphadenectomy) and gastrointestinal reconstruction. A total of 26 patients(15%) in both groups developed postoperative gastroparesis, 6 patients in the side-to-side anastomosis group(6/72, 8%) and 20 patients in the end-to-side anastomosis group(20/103, 20%), the difference was statistically significant (P=0.04); the median hospital stay in the side-to-side anastomosis group was 20 days, and the median hospital stay in the end-to-side anastomosis group was 25 days, the difference was statistically significant(P=0.01). There was no statistically significant difference between the general condition and medical history of the two groups of patients, such as age, gender, BMI, etc.(P>0.05); the operation time, bleeding volume, postoperative anastomotic complications(non-gastric paralysis), other complications and total hospitalization costs were no statistically significant differences(P>0.05). Conclusion: Gastric-jejunal side-to-side anastomosis can reduce the risk of postoperative gastroparesis and shorten the length of hospitalization. Linear stapler is easy to operate and may reduce anastomosis related complications.
 HOYA Y,MITSUMORI N,YANAGA K.The advantages and disadvantages of a Roux-en-Y reconstruction after a distal gastrectomy for gastric cancer[J].Surg Today,2009,39(8):647-651.
 MATSUI H,OKAMOTO Y,NABESHIMA K,et al.Endoscopy-assisted anasto-mosis:a modified technique for laparoscopic side-to-side esophagojejunostomy following a total gastrectomy[J].A J Endosc Surg,2011,4(1):107-111.
 AKIYAMA H,TSURUMARU M,UDAGAWA H,et al.Esophageal cancer[J].C Probl Surg,2009,34(10):790-792.
 MURATA Y,TANEMURA A,KATO H,et al.Superiority of stapled side-to-side gastrojejunostomy over conventional hand-sewn end-to-side gastrojejunostomy for reducing the risk of primary delayed gastric emptying after subtotal stomach-preserving pancreaticoduodenectomy[J].Surg Today,2017,47(8):1007-1017.
 NAKAMURA T,AMBO Y,NOJI T,et al.Reduction of the incidence of delayed gastric emptying in side-to-side gastrojejunostomy in subtotal stomach-preserving pancreaticoduodenectomy[J].J Gastrointest Surg,2015,19(8):1425-1432.
 CHANG K,PATEL M,YOON S et al.Linear-stapled side-to-side esophagojejunostomy with hand-sewn closure of the common enterotomy after prophylactic and therapeutic total gastrectomy[J].J Gastrointest Surg,2017,21(4):712-722.