前交叉韧带（anterior cruciate ligament，ACL）损伤及修复一直是医学研究的重要课题，不管是在临床应用还在基础研究中。由于其内源性修复障碍，手术重建一直是治疗ACL损伤的金标准。但是随着科学研究的发展，手术治疗被发现有诸多弊端，像术后骨关节炎、二次损伤和撕裂等，而且手术重建后韧带功能无法恢复如初，严重影响患者的行动。因此，探索更加有效的治疗方法是当前研究的目标。目前对ACL损伤后修复方法主要集中在探讨促进内源性修复机制、韧带重建手术改进、富血小板血浆促进修复、力学生长因子促进修复、通过基因转染促进修复和干细胞促进修复等几方面。本文作者就ACL的损伤类型、损伤机制以及修复方法作一综述。

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