网站首页期刊介绍通知公告编 委 会投稿须知电子期刊广告合作联系我们
最新消息:
依帕司他联合丹参酮ⅡA磺酸钠注射液对糖尿病肾病的疗效及对体液免疫、炎症因子的影响
作者:周婷婷  甘元琼  唐竞远 
单位:四川省大竹县人民医院 内分泌血液科, 四川 达州 635100
关键词:依帕司他 丹参酮ⅡA磺酸钠 糖尿病肾病 体液免疫 炎症因子 
分类号:R587.2
出版年·卷·期(页码):2020·39·第五期(598-601)
摘要:

目的:探讨依帕司他联合丹参酮ⅡA磺酸钠注射液对糖尿病肾病的疗效及对体液免疫、炎症因子的影响。方法:将2016年1月至2018年1月我院内分泌血液科收治的80例糖尿病肾病患者随机分为观察组和对照组,对照组采用依帕司他治疗,观察组采用依帕司他联合丹参酮ⅡA磺酸钠注射液治疗,观察两组临床疗效及体液免疫水平、炎症因子水平。结果:观察组治疗总有效率显著高于对照组(P<0.05),血尿素氮、肌酐及24 h尿蛋白水平均显著低于对照组(P<0.05),血IgG、IgA及IgM水平均显著低于对照组(P<0.05),血C-反应蛋白、白介素-6及肿瘤坏死因子-α水平均显著低于对照组(P<0.05)。结论:依帕司他联合丹参酮ⅡA磺酸钠注射液可提高糖尿病肾病临床疗效,改善患者体液免疫及炎症因子水平。

Objective: To investigate the effects of epalrestat combined with tanshinone ⅡA sodium sulfonate injection on clinical efficacy, humoral immunity and inflammatory factors in patients with diabetic nephropathy. Methods: From January 2016 to January 2018, 80 diabetic nephropathy patients admitted to the Department of Endocrinology and Hematology of our hospital were randomly divided into the observation group and the control group. Patients in the control group were treated with epalrestat, and the patients in the observation group were treated with epalrestat combined with tanshinone IIA sulfonate injection. The clinical efficacy, humoral immune level and inflammatory factor level of the two groups were observed. Results: The total effective rate of the observation group was significantly higher than that of the control group (P<0.05).The levels of urea nitrogen, creatinine and 24-hour urinary protein in the observation group were significantly lower than those of the control group (P<0.05). The levels of IgG, IgA and IgM in the observation group were significantly lower than those of the control group (P<0.05).The levels of C-reactive protein, interleukin-6 and tumor necrosis factor-α in the observation group were significantly lower than those of the control group (P<0.05). Conclusion: Epalrestat combined with sodium tanshinone IIA sulfonate injection can improve the clinical efficacy of diabetic nephropathy, improve the levels of humoral immunity and inflammatory factors in the patients.

参考文献:

[1] ZHANG Y L,XU J W,WU X H,et al.Relaxant Effect of Sodium Tanshinone ⅡA Sulphonate on Mouse Tracheal Smooth Muscle[J].Planta Medica,2016,83(7):624-630.
[2] CHEN F,LI H,ZHU G,et al.Sodium tanshinone ⅡA sulfonate improves inflammation,aortic endothelial cell apoptosis,disseminated intravascular coagulation and multiple organ damage in a rat heat stroke model[J].Molecular Medicine Reports,2017,16(1):87-94.
[3] 费扬,余少初,孙丽琴,等.前列地尔对糖尿病下肢血管病变患者炎症因子和氧化应激的影响[J].中华全科医学,2017,15(5):789-791.
[4] JI B,ZHOU F,HAN L,et al.Sodium tanshinone ⅡA sulfonate enhances effectiveness Rt-PA treatment in acute ischemic stroke patients associated with ameliorating blood-brain barrier damage[J].Translational Stroke Research,2017,8(4):1-7.
[5] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2017年版)[J].中国糖尿病杂志,2018,10(1):33-50.
[6] 李君玲,仝小林.早期诊断2型糖尿病肾病指标[C]//国际中医糖尿病大会暨国际中医药糖尿病临床研究联盟成立大会.2011.
[7] OUYANG D S,HUANG W H,DAN C,et al.Kinetics of cytochrome P450 enzymes for metabolism of sodium tanshinone ⅡA sulfonate in vitro[J].Chinese Medicine,2016,11(1):11.
[8] 韩昕健,郝伟,孙秀燕,等.CD36在糖尿病肾病患者肾组织中的表达及调控Wnt/β-catenin信号通路对人肾小管上皮细胞增殖凋亡的实验研究[J].东南大学学报(医学版),2017,36(5):704-710.
[9] 侯保健,蔡莉,胡菊萍.前列地尔及依帕司他治疗早期2型糖尿病肾病蛋白尿的疗效及安全性分析[J].糖尿病新世界,2016,19(14):1-2.
[10] 李阳,孔彩霞,肖方喜,等.加巴喷汀联合依帕司他治疗糖尿病痛性神经病变的效果[J].现代医学,2019,47(8):935-939.
[11] LI D,WANG J,SUN D,et al.Tanshinone ⅡA sulfonate protects against cigarette smoke-induced COPD and down-regulation of CFTR in mice[J].Scientific Reports,2018,8(1):376.
[12] 宋诵文,曾琦,吴新民,等.温肾化浊、逐瘀通络为主治疗糖尿病肾病的临床观察[J].世界中医药,2017,12(9):2019-2022.
[13] DONG X,NIU Y,DING Y,et al.Formulation and drug loading features of nano-erythrocytes[J].Nanoscale Research Letters,2017,12(1):202.
[14] XIE J,LIU J H,LIU H,et al.Tanshinone ⅡA combined with adriamycin inhibited malignant biological behaviors of NSCLC A549 cell line in a synergistic way[J].Bmc Cancer,2016,16(1):899.
[15] 李志伟,李彩红,郭辉.联合检测糖化血红蛋白、胱抑素C、血清淀粉样蛋白A、视黄醇结合蛋白对早期糖尿病肾病的诊断价值[J].现代医学,2019,47(5):590-593.
[16] 陈铁龙,祝光礼,张旭栋,等.TNF-α诱导人脐静脉血管内皮细胞凋亡和炎症机制研究[J].中华全科医学,2018,16(2):184-187.
[17] CAI Y,ZHANG W,CHEN Z,et al.Recent insights into the biological activities and drug delivery systems of tanshinones[J].Int J Nanomed,2016,11(1):121-130.
[18] DING L,WANG S,WANG W,et al.Tanshinone ⅡA affects autophagy and apoptosis of glioma cells by inhibiting phosphatidylinositol 3-Kinase/Akt/Mammalian target of rapamycin signaling pathway[J].Pharmacology,2016,99(1-2):99.

服务与反馈:
文章下载】【发表评论】【查看评论】【加入收藏
提示:您还未登录,请登录!点此登录
您是第 373536 位访问者


 ©《现代医学》编辑部
联系电话:025-83272481;83272479
电子邮件: xdyx@pub.seu.edu.cn

苏ICP备09058541