Objective: To investigate the epidemiological status of uterine leiomyoma in Xinghua area of Jiangsu Province, and to analyze the risk factors of disease, provide evidence for the prevention and treatment of uterine leiomyoma.Methods: Patients with uterine leiomyoma diagnosed in XinghuaPeople's Hospital from June 2016 to May 2018 and subjects who received health examinations at the same time in the hospital's physical examination center were selected for epidemiological studies using case-control studies. The questionnaire was surveyed, the results were entered into the database, and the data were analyzed by single factor and multivariate logistic regression, and follow-up was performed.Results: A total of 1 273 women were included in the study, including 213 women with uterine leiomyomas (case group) and 1 060 healthy women (control group). There was no significant difference in age, marital status, number of pregnancies and complications, physical exercise, alcohol consumption, and family history of uterine disease between the two groups (all P>0.05). However, body mass index (P=0.043), education (P=0.041), smoking (P=0.030), frequent intake of caffeine (P=0.019), frequent consumption of milk or soy food (P=0.025), the frequent use of oral contraceptives (P=0.034), these results were statistically different between the two groups. Multivariate Logistic regression analysis showed that frequent consumption of soy foods (OR=7.349,95% CI 5.081-9.454,P=0.039) and frequent use of oral contraceptives (OR=8.103,95% CI 4.486-12.583,P=0.018) were independent risk factors of uterine leiomyoma.Conclusion: Frequent consumption of soy foods, as well as frequent use of oral contraceptives, can lead to high risk of uterine fibroids, and it is recommended in clinical practice to conduct appropriate prevention education for uterine leiomyoma.
 SPARIC R,MIRKOVIC L,MALVASI A,et al.Epidemiology of uterine myomas:a review[J].Int J Fertil Steril,2016,9(4):424-435.
 DAGUR G,SUH Y,WARREN K,et al.Urological complications of uterine leiomyoma:a review of literature[J].Int Urol Nephrol,2016,48(6):941-948.
 GURUSAMY K S,VAUGHAN J,FRASER I S,et al.Medical therapies for uterine fibroids-a systematic review and network meta-analysis of randomised controlled trials[J].PLoS One,2016,11(2):e0149631.
 NOTHNICK W B.Non-coding RNAs in uterine development,function and disease[J].Adv Exp Med Biol,2016,886:171-189.
 COMMANDEUR A E,STYER A K,TEIXEIRA J M.Epidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth[J].Hum Reprod Update,2015,21(5):593-615.
 MORAVEK M B,BULUN S E.Endocrinology of uterine fibroids:steroid hormones,stem cells,and genetic contribution[J].Curr Opin Obstet Gynecol,2015,27(4):276-283.
 SHEN Y,XU Q,XU J,et al.Environmental exposure and risk of uterine leiomyoma:an epidemiologic survey[J].Eur Rev Med Pharmacol Sci,2013,17(23):3249-3256.
 BAIRD D D,HARMON Q E,UPSON K,et al.A prospective,ultrasound-based study to evaluate risk factors for uterine fibroid incidence and growth:methods and results of recruitment[J].J Womens Health (Larchmt),2015,24(11):907-915.
 KORKMAZ V,OZKAYA E,OZER KADIFE S,et al.Investigation of cardiovascular disease risk in women with uterine leiomyomas[J].Ir J Med Sci,2016,185(3):689-693.
 ALEKSANDROVYCH V,BEREZA T,SAJEWICZ M,et al.Uterine fibroid:common features of widespread tumor (Review article)[J].Folia Med Cracov,2015,55(1):61-75.
 FLAKE G P,ANDERSEN J,DIXON D.Etiology and pathogenesis of uterine leiomyomas:a review[J].Environ Health Perspect,2003,111(8):1037-1054.
 WISE L A,PALMER J R,HARLOW B L,et al.Reproductive factors,hormonal contraception,and risk of uterine leiomyomata in African-American women:a prospective study[J].Am J Epidemiol,2004,159(2):113-123.
 SAKATA R,GRANT E J,OZASA K.Long-term follow-up of atomic bomb survivors[J].Maturitas,2012,72(2):99-103.
 BAIRD D D,DUNSON D B,HILL M C,et al.Association of physical activity with development of uterine leiomyoma[J].Am J Epidemiol,2007,165(2):157-163.
 WISE L A,PALMER J R,HARLOW B L,et al.Risk of uterine leiomyomata in relation to tobacco,alcohol and caffeine consumption in the Black Women's Health Study[J].Hum Reprod,2004,19(8):1746-1754.
 HE Y,ZENG Q,DONG S,et al.Associations between uterine fibroids and lifestyles including diet,physical activity and stress:a case-control study in China[J].Asia Pac J Clin Nutr,2013,22(1):109-117.
 MAHALINGAIAH S,HART J E,LADEN F,et al.Air pollution and risk of uterine leiomyomata[J].Epidemiology,2014,25(5):682-688.
 LETHABY A,VOLLENHOVEN B.Fibroids (uterine myomatosis,leiomyomas)[J].BMJ Clin Evid,2015,2015.pii:0814.pii:0814.
 WISE L A,RADIN R G,PALMER J R,et al.Intake of fruit,vegetables,and carotenoids in relation to risk of uterine leiomyomata[J].Am J Clin Nutr,2011,94(6):1620-1631.
 SHEN Q,HUA Y,JIANG W,et al.Effects of mifepristone on uterine leiomyoma in premenopausal women:a meta-analysis[J].Fertil Steril,2013,100(6):1722-6.e1-10.
 QIN J,YANG T,KONG F,et al.Oral contraceptive use and uterine leiomyoma risk:a meta-analysis based on cohort and case-control studies[J].Arch Gynecol Obstet,2013,288(1):139-148.
 CHIAFFARINO F,PARAZZINI F,LA VECCHIA C,et al.Use of oral contraceptives and uterine fibroids:results from a case-control study[J].Br J Obstet Gynaecol,1999,106(8):857-860.