参芪扶正注射液联合放疗对晚期肺癌患者血清基质金属蛋白酶和碱性成纤维细胞生长因子的影响-现代医学

参芪扶正注射液联合放疗对晚期肺癌患者血清基质金属蛋白酶和碱性成纤维细胞生长因子的影响

单位：1. 河北省石家庄市第三医院药剂科, 河北石家庄 050011;
2. 沧州渤海新区中捷医院检验科, 河北沧州 061000;
3. 冀中能源邢台矿业集团有限责任公司总医院护理部, 河北邢台 054000

分类号：R734.2

出版年·卷·期（页码）：2020·48·第二期（179-183）

摘要：

目的： 探讨参芪扶正注射液联合放疗对晚期肺癌患者血清基质金属蛋白酶和碱性成纤维细胞生长因子的影响。方法： 选取2014年3月至2018年6月间在我院治疗的86例晚期肺癌患者，随机分为观察组和对照组，各43例。观察组患者在放疗的同时加用参芪扶正注射液治疗，对照组患者采用放射治疗，比较两组患者血清MMP-7、MMP-9及bFGF水平、临床总有效率及不良反应总发生率。结果： 治疗前后比较，观察组患者MMP-7、MMP-9及bFGF水平的减少值均大于对照组，差异具有统计学意义（P<0.05）；观察组临床总有效率显著高于对照组的（P<0.05）；观察疗组不良反应总发生率显著低于对照组（P<0.05）。结论： 参芪扶正注射液联合放疗治疗晚期肺癌可显著降低患者血清MMP-7、MMP-9及bFGF水平，减轻不良反应，适宜临床推广。

Objective: To investigate the effects of Shenqi Fuzheng injection combined with radiotherapy on serum matrix metalloproteinase and basic fibroblast growth factor in patients with advanced lung cancer. Methods: Eighty-six patients with advanced lung cancer who were treated in our hospital from March 2014 to June 2018 were randomly divided into observation group and control group, 43 cases in each group. Patients in the observation group were treated with Shenqi Fuzheng injection and radiotherapy, and radiotherapy was used in the control group. The serum levels of MMP-7, MMP-9, bFGF, total clinical effective rate, and total adverse reactions were compared between the two groups. Results: Before treatment and after treatment, the reduction of MMP-7, MMP-9 and bFGF levels in the observation group were higher than those in the control group, the difference being statistically significant (P<0.05). The total clinical efficiency of the observation group was significantly higher than that of the control group (P<0.05). The total incidence of adverse reactions in the treatment group was significantly lower than that in the control group (P<0.05). Conclusion: Shenqi Fuzheng injection combined with radiotherapy for advanced lung cancer can significantly reduce serum MMP-7, MMP-9 and bFGF levels, reduce adverse reactions, and is worthy of clinical promotion.

参考文献：

[1] 陈伦音,王颖峰,贺珊珊,等.参芪扶正注射液辅助纳洛酮与BiPAP呼吸机治疗对AECOPD伴Ⅱ型呼吸衰竭患者血清炎性因子、免疫功能及血气分析指标的影响[J].海南医学院学报,2017,23(16):2176-2179.
[2] 唐杰,何海浪,许荣龙,等.参芪扶正注射液联合放疗治疗非小细胞肺癌的Meta分析[J].中国实验方剂学杂志,2015,21(1):203-207.
[3] SANTOS M F,MANNAM V K,CRAFT B S,et al.Comparative analysis ofinnate immune system function in metastatic breast,colorectal,andprostate cancer patients with circulating tumor cells[J].Exp MolPathol,2014,96(3):367-374.
[4] 刘志.中西医结合治疗晚期非小细胞肺癌疗效观察[J].中国实用医药,2016,11(27):247-248.
[5] 任乐.参芪扶正注射液对晚期非小细胞肺癌化疗患者造血和免疫功能的影响[J].中国肿瘤临床与康复,2014,21(4):463-465.
[6] DANG J,LI G,MA L,et al.Predictors of grade ≥ 2 and grade ≥ 3radiation pneumonitis in patients with locally advanced non-small cell lung cancer treated with three-dimensional conformalradiotherapy[J].Acta Oncologica,2013,52:1175-1180.
[7] 冯高华,刘美秀.扶正抗瘤方辅助化疗对晚期非小细胞肺癌患者血清CEA、bFGF及MMP-9的影响[J].中国肿瘤临床与康复,2018,25(8):904-907.
[8] GAO H,LIU J,SONG N.Application of target peptide in siRNA delivery for the research of lung cancer therapy[J].Chin J Lung Cancer,2014,17(9):674-678.
[9] 潘彦康,黄敏,区梅.参芪扶正注射液辅助化疗治疗非小细胞肺癌临床观察[J].中国临床医生杂志,2008,36(4):43.
[10] 班媛媛,李道胜.基质金属蛋白酶-7和碱性成纤维细胞生长因子在非小细胞肺癌中的表达意义及相关性[J].实用医技杂志,2014,21(9):930-934.
[11] 李斐斐,吴皓,陈露,等.益肺清化颗粒对Lewis肺癌小鼠血管内皮细胞生长因子及其受体的影响[J].中国中医药信息杂志,2013,20(12):29-31.
[12] NASGASHIO R,SATO Y,MATSUMOTO T,et al.The balance between the expressions of hASH1 and HES1 differs between large cell neuroendocrine carcinoma and small cell carcinoma of the lung[J].Lung Cancer,2011,74(3):405-410.
[13] 李英,董良,李海金,等.非小细胞肺癌血清VEGF、bFGF和TNF-α的临床意义[J].肿瘤学杂志,2013,19(1):50-54.
[14] NAKOMAN C,RESMI H,AY O,et al.Effects of basic fibroblast factor (bFGF) on MMP-2,TIMP-2,and type-1 collagen levelsin human-lung-carcinoma fibroblasts[J].Biochimie,2005,87(3-4):343-351.

服务与反馈：

【文章下载】【发表评论】【查看评论】【加入收藏】

提示：您还未登录，请登录！点此登录