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肿瘤浸润炎症细胞在鼻咽癌中分布及预后相关性分析
作者:孙瑜宁  李迎喜  张恩东 
单位:青岛大学医学院附威海医院 耳鼻喉科, 山东 青岛 264200
关键词:鼻咽癌 肿瘤浸润炎症细胞 免疫微环境 预后 
分类号:R739.63
出版年·卷·期(页码):2020·39·第二期(172-179)
摘要:

目的: 分析肿瘤浸润炎症细胞在鼻咽癌中分布及预后相关性。方法: 选取2009年10月至2013年10月间在本院进行治疗鼻咽癌患者石蜡标本158例,免疫组化法分析患者机体内FOXP3、CD8+、CD4+、NE+、CD56+、CD20+、CD83+、CD1a+及tryptase+细胞分布、含量和患者预后相关性状况。结果: 依据炎症细胞密度将其分成高密度组与低密度组,CD3+、CD20+、CD83+及tryptase+浸润密度和患者不同病理分类相关(P<0.05),FOXP3+、NE+及tryptase+浸润密度和患者不同N分级相关(P<0.05),FOXP3+、NE+浸润密度和患者不同临床分期相关(P<0.05);CD8+、tryptase+、NE+及FOXP3+低密度比高密度生存率高,CD1a+、CD56+高密度比低密度生存率高,差异均有统计学意义(P<0.05)。结论: 肿瘤浸润肥大细胞、细胞毒性T细胞及调节性T细胞含量与鼻咽癌患者不良预后有紧密联系,CD56+NK细胞与CD1a+未成熟树突状细胞和患者良好预后有联系。

Objective: To analyze the distribution and prognosis of tumor infiltrating inflammatory cells in nasopharyngeal carcinoma.Methods: From October 2009 to October 2013 paraffin specimens of 158 patients with nasopharyngeal carcinoma in our hospital were analyzed by immunohistochemistry to detect FOXP3, CD8+, CD4+, NE+, CD56+, CD20+, CD83+, CD1a+ and tryptase+ cell distribution, content and prognosis condition.Results: According to the density of inflammatory cells into the high density group and low density group, CD3+, CD20+, CD83+ and tryptase+ infiltration density was correlated with different pathological classification, FOXP3, NE+ and tryptase+ infiltration density was correlated with different N grade (P<0.05), FOXP3, NE+ infiltration density was correlated with different clinical stages (P<0.05). The survival rate of CD8+, tryptase, NE+ and FOXP3+ was higher than that of high density group, and the survival rate of CD1a+ and CD56+ was higher than that of low density, the difference was statistically significant (P<0.05). Conclusion: The content of tumor infiltrating mast cells, cytotoxic T cells and regulatory T cells is closely related to the poor prognosis of nasopharyngeal carcinoma patients. CD56+ NK cells are associated with the prognosis of CD1a+ immature dendritic cells and patients.

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