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宫颈癌组织中Cep55与FoxM1蛋白表达与临床病理特征及预后的相关性分析
作者:李志强  魏艳玲  高静 
单位:河北北方学院附属第二医院 病理科, 河北 张家口 075100
关键词:宫颈癌 中心相关蛋白Cep55 叉头转录因子FoxM1 免疫组织化 病理特征 预后 
分类号:R737.33
出版年·卷·期(页码):2020·39·第二期(162-167)
摘要:

目的: 分析宫颈癌组织中心相关蛋白Cep55(Cep55)与叉头转录因子(FoxM1)蛋白的表达情况,并探讨Cep55与FoxM1蛋白在宫颈癌组织中的临床病理特征及预后的相关性。方法: 选取本院2010年1月至2013年4月收治的124例宫颈癌患者作为研究对象,采用回顾性分析法分析所有患者的临床及随访资料,根据其资料结果收集124例宫颈癌患者的124份癌组织标本(研究组)及124份其他良性宫颈疾病的正常组织标本(对照组)作为研究对象,所有组织标本均行Cep55与FoxM1蛋白的检测,分析宫颈癌组织中Cep55与FoxM1蛋白的表达与患者临床病理特征和预后的关系。结果: (1)宫颈癌组织中Cep55及FoxM1蛋白阳性表达率分为75.00%(93/124)、77.42%(96/124)(P<0.05);(2)Cep55及FoxM1的表达与宫颈癌患者的年龄、病理类型及累及阴道残端情况均无明显关系(P>0.05);Cep55及FoxM1的表达与宫颈癌患者淋巴结转移、FIGO分期、分化程度及肌层浸润深度有显著相关(P<0.05);(3)经单因素分析得出:FIGOⅡ期、低分化、肌层浸润深度≥ 1/2及Cep55及FoxM1蛋白阳性患者其生存时间均显著缩短(P<0.05);(4)经多因素Cox比例风险回归模型分析得出:FIGOⅡ期、低分化、肌层浸润深度≥ 1/2及Cep55及FoxM1蛋白阳性均为影响宫颈癌患者预后的独立危险因素(P<0.05)。结论: Cep55及FoxM1蛋白在宫颈癌癌变组织中以高水平表达,随着患者FIGOⅡ期、低分化、肌层浸润深度≥ 1/2,其高表达率均上升,且联合FIGOⅡ期、低分化、肌层浸润深度≥ 1/2共同为影响宫颈癌患者预后的独立危险因素。

Objective: To investigate expression of centrosomal protein (Cep55) and forkhead transcription factor (FoxM1) in cervical cancer tissue, and to analyze its correlation with clinicopathological features and prognosis. Methods: The clinical data and the follow-up data of 124 patients with cervical cancer admitted to our hospital from January 2010 to April 2013 were retrospectively analyzed. The Cep55 and FoxM1 protein expression in the cancer tissues (study group, n=124) and adjacent normal tissues (control group, n=124) were detected. Then the relationships between expression levels and clinicopathological features and prognosis were analyzed. Results: (1) The positive expression rates of Cep55 and FoxM1 protein in cervical cancer tissues were 75.00% (93/124) and 77.42% (96/124) respectively (P<0.05). (2) The expression of Cep55 and FoxM1 were not correlated with age, pathological type and vaginal involvement of cervical cancer patients (P>0.05), while related with the lymph node metastasis, FIGO stage, differentiation degree and depth of myometrial invasion in cervical cancer patients (P<0.05).(3) Univariate analysis showed that the survival time of patients with FIGOII stage, poor differentiation, myometrial invasion depth ≥ 1/2 and positive Cep55 and FoxM1 protein were significantly shorter (P<0.05). (4) The multivariate Cox proportional hazards regression model showed that FIGO II stage, poor differentiation, depth of myometrial invasion ≥ 1/2, and positive Cep55 and FoxM1 protein were independent risk factors for the prognosis of patients with cervical cancer (P<0.05). Conclusion: Cep55 and FoxM1 proteins are expressed at high levels in cervical cancerous tissues, which are even higher among patients with FIGO II stage, poor differentiation, and myometrial invasion depth ≥ 1/2, since these factors are independent risk factors for the prognosis of patients with cervical cancer.

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