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创伤性脊髓损伤中神经元轴突变性机制研究
作者:宋彬彬  刘小鹏  董文洲  贾炳泉  齐月英  于佳 
单位:北京中医药大学附属北京老年医院 老年病临床与康复研究所, 北京 100095
关键词:轴突变性 创伤性脊髓损伤 NAD+ calpain MAPK 
分类号:R744.9
出版年·卷·期(页码):2020·48·第一期(130-134)
摘要:

创伤性脊髓损伤(traumatic spinal cord injury,TSCI)是日常生活中发生的脊髓急剧受损,使患者行为和生存受到严重影响。脊髓中轴突是中枢神经系统中神经信号传导的重要桥梁,创伤性脊髓损伤可引起不可逆的轴突变性(肿胀、断裂),破坏神经元的结构和功能。文章将对创伤性脊髓损伤中轴突变性的发生发展过程和分子机制进行综述。

Objective: Traumatic spinal cord injury(TSCI) is an acute injury of spinal cord, which seriously affects the behavior and survival of patients. The axon in spinal cord is an bridge for the conduction of nerve signals in the central nervous system. TSCI cause irreversible axonal degeneration(axons swell, break),which may destroy the structure and function of neurons. This review will focus on the development and molecular mechanism of axonal degeneration in TSCI.

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