[1] AHUJA C S,WILSON J R,NORI S,et al.Traumatic spinal cord injury[J].Nat Rev Dis Primers,2017,3:17018.
[2] ROWLAND J W,HAWRYLUK G W,KWON B,et al.Current status of acute spinal cord injury pathophysiology and emerging therapies:promise on the horizon[J].Neurosurg Focus,2008,25(5):E2.
[3] HASSANNEJAD Z,YOUSEFIFARD M,AZIZI Y,et al.Axonal degeneration and demyelination following traumatic spinal cord injury:a systematic review and meta-analysis[J].J Chem Neuroanat,2019,97:9-22.
[4] KERSCHENSTEINER M,SCHWAB M E,LICHTMAN J W,et al.In vivo imaging of axonal degeneration and regeneration in the injured spinal cord[J].Nat Med,2005,11(5):572-577.
[5] SCHAFFRAN B,HILTON B J,BRADKE F.Imaging in vivo dynamics of sensory axon responses to CNS injury[J].Exp Neurol,2019,317:110-118.
[6] HILL C E.A view from the ending:axonal dieback and regeneration following SCI[J].Neurosci Lett,2017,652:11-24.
[7] GILLEY J,COLEMAN M P.Endogenous Nmnat 2 is an essential survival factor for maintenance of healthy axons[J].PLoS Biol,2010,8(1):e1000300.
[8] RODERER P,KLATT L,JOHN F,et al.Increased ROS Level in Spinal Cord of Wobbler Mice due to Nmnat2 Downregulation[J].Mol Neurobiol,2018,55(11):8414-8424.
[9] GEISLER S,HUANG S X,STRICKLAND A,et al.Gene therapy targeting SARM1 blocks pathological axon degeneration in mice[J].J Exp Med,2019,216(2):294-303.
[10] ESSUMAN K,SUMMERS D W,SASAKI Y,et al.The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD (+) Cleavage Activity that Promotes Pathological Axonal Degeneration[J].Neuron,2017,93(6):1334-1343 e1335.
[11] LORETO A,DI STEFANO M,GERING M,et al.Wallerian Degeneration Is Executed by an NMN-SARM1-Dependent Late Ca (2+) Influx but Only Modestly Influenced by Mitochondria[J].Cell Rep,2015,13(11):2539-2552.
[12] DI STEFANO M,NASCIMENTO-FERREIRA I,ORSOMANDO G,et al.A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration[J].Cell Death Differ,2015,22(5):731-742.
[13] VILLEGAS R,MARTINEZ N W,LILLO J,et al.Calcium release from intra-axonal endoplasmic reticulum leads to axon degeneration through mitochondrial dysfunction[J].J Neurosci,2014,34(21):7179-7189.
[14] OREM B C,PELISCH N,WILLIAMS J,et al.Intracellular calcium release through IP3R or RyR contributes to secondary axonal degeneration[J].Neurobiol Dis,2017,106:235-243.
[15] ZATZ M,STARLING A.Calpains and disease[J].N Engl J Med,2005,352(23):2413-2423.
[16] MA M.Role of calpains in the injury-induced dysfunction and degeneration of the mammalian axon[J].Neurobiol Dis,2013,60:61-79.
[17] ZHAI Q,WANG J,KIM A,et al.Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration[J].Neuron,2003,39(2):217-225.
[18] WANG M S,WU Y,CULVER D G,et al.Pathogenesis of axonal degeneration:parallels between Wallerian degeneration and vincristine neuropathy[J].J Neuropathol Exp Neurol,2000,59(7):599-606.
[19] MA M,FERGUSON T A,SCHOCH K M,et al.Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration[J].Neurobiol Dis,2013,56:34-46.
[20] HANNA R A,CAMPBELL R L,DAVIES P L.Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin[J].Nature,2008,456(7220):409-412.
[21] YANG J,WEIMER R M,KALLOP D,et al.Regulation of axon degeneration after injury and in development by the endogenous calpain inhibitor calpastatin[J].Neuron,2013,80(5):1175-1189.
[22] YANG J,WU Z,RENIER N,et al.Pathological axonal death through a MAPK cascade that triggers a local energy deficit[J].Cell,2015,160(1-2):161-176.
[23] ANTONSSON B,KASSEL D B,DI PAOLO G,et al.Identification of in vitro phosphorylation sites in the growth cone protein SCG10.Effect Of phosphorylation site mutants on microtubule-destabilizing activity[J].J Biol Chem,1998,273(14):8439-8446.
[24] SHIN J E,MILLER B R,BABETTO E,et al.SCG10 is a JNK target in the axonal degeneration pathway[J].Proc Natl Acad Sci U S A,2012,109(52):E3696-3705.
[25] HE M,DING Y,CHU C,et al.Autophagy induction stabilizes microtubules and promotes axon regeneration after spinal cord injury[J].Proc Natl Acad Sci U S A,2016,113(40):11324-11329.
[26] HOU S T,JIANG S X,SMITH R A.Permissive and repulsive cues and signalling pathways of axonal outgrowth and regeneration[J].Int Rev Cell Mol Biol,2008,267:125-181.
[27] LIZ M A,MAR F M,SANTOS T E,et al.Neuronal deletion of GSK3beta increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2[J].BMC Biol,2014,12:47.
[28] TSUCHIDA M,NAKAMACHI T,SUGIYAMA K,et al.PACAP stimulates functional recovery after spinal cord injury through axonal regeneration[J].J Mol Neurosci,2014,54(3):380-387.
[29] YU Y,JIAN M Y,WANG Y Z,et al.Propofol ameliorates calpain-induced collapsin response mediator protein-2 proteolysis in traumatic brain injury in rats[J].Chin Med J (Engl),2015,128(7):919-927.
[30] TAGHIAN K,LEE J Y,PETRATOS S.Phosphorylation and cleavage of the family of collapsin response mediator proteins may play a central role in neurodegeneration after CNS trauma[J].J Neurotrauma,2012,29(9):1728-1735.
[31] 杨磊,赵海康,窦群立,等.康复治疗对脊髓损伤患者近期及远期社会、心理、生理状况的影响[J].现代医学,2019,47(1):56-59. |