Objective: To compare the clinical effects of continuous and intermittent renal replacement therapy (RRT) on multiple organ dysfunction syndrome. Methods: From October 2015 to March 2018, patients with multiple organ dysfunction syndrome treated with RRT in our intensive care unit (ICU) were selected as the study subjects. Patients were randomized to receive either CRRT (n=44) or IRRT (n=46). The primary outcome measure was survival 28 days after the end of RRT. Secondary outcome measures included 28-day-, 60-day-, all cause intrahospital mortality, days until death (on ICU), days of ICU/hospital stay, days of RRT/dialysis-free days, total days on vasopressors/mechanical ventilation, and course of disease severity. Results: Survival at 28 days after RRT, 28-day-, 60-day-and all-cause intrahospital mortality rates were not different between the two groups (P> 0.05).There were no significant differences in the days until death (on ICU), ICU hospitalization time, hospitalization time, the cause of death, RRT treatment time, dialysis-free time and the total duration of mechanical ventilation between the two groups (P> 0.05). There was no significant difference in the incidence of most adverse events between the two groups (P> 0.05). Compared with the CRRT group, the IRRT group had fewer hypothermia events (18.2% vs. 4.3%, P<0.05). Conclusion: In patients with acute renal failure as part of multiple-organ dysfunction syndrome, CRRT or IRRT has the same clinical efficacy.
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