Objective: To investigate the abnormalcardiovascular ultrasound results in patients diagnosed with acute exacerbation chronic obstructive pulmonary disease (AECOPD) combined with elevated brain natriuretic peptide (BNP), and to discuss the clinical significance of cardiovascular dysfunction. Methods: According to the level of BNP, AECOPD patients were divided into Group 1 (BNP 100-400 ng·L-1) and Group 2 (BNP> 400 ng·L-1). Echocardiogram and cervical vascular ultrasound results were collected and compared between the two groups. Results: Totally, 151 subjects were included. The right ventricular internal diameter (RVID), left arterial diameter (LAD), pulmonary arterial systolic pressure (PASP) of Group 2 were significantly higher than those of Group 1 (P<0.05 for all), and the left ventricular ejection fraction (LVEF) was significantly lower than that of Group 1 (P<0.05). There were no significant inter-group differences of the aortic root inside diameter (AORD), the left ventricular end-diastolic diameter (LVIDd), and the left ventricular end-systolic diameter (LVIDs) (P>0.05 for all). The peak values of bilateral total blood flow and internal carotid blood flow in Group 2 were lower than those in Group 1 (both P<0.05). No significant differences between the two groups were found in bilateral cervical vascular intimal thickening and rough intima plaque incidence (both P>0.05). Conclusion: Patients suffered from AECOPD combined with elevated BNP, especially those with BNP higher than 400 ng·L-1 are more frequently associated with cardiac enlargement, increased pulmonary arterial pressure, lower ejection fraction, and lower neck blood flow. More attention should be paid to the clinic, and the evaluation of cardiovascular ultrasound should be performed, so as to timely and comprehensively understand the cardiovascular reserve function of the patient, which brings more accurate individual treatment and clinical benefit.
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