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复发性流产与调节性T细胞及IL-10的相关性分析
作者:袁惠芝  郑玉华  冯敏清  谢佳彬 
单位:佛山市妇幼保健院 妇科, 广东 佛山 528000
关键词:CD4+CD25+Treg细胞 白介素-10 复发性流产 相关分析 
分类号:R714.21
出版年·卷·期(页码):2019·47·第十二期(1487-1490)
摘要:

目的: 探究复发性流产与孕早期调节性T细胞及白介素-10(IL-10)水平的相关性。方法: 选取2016年3月至2017年12月于我院就诊的早期流产的复发性流产患者22例为复发性流产组,选择同期正常早孕但要求终止妊娠的患者37例为健康对照组,对比两组外周血及蜕膜组织中CD4+CD25bright频率、CD4+CD25dim频率、CD4+CD25bright/CD4+及外周血中IL-10水平,应用Logistic回归分析复发性流产的独立危险因素。结果: 复发性流产组外周血中CD4+CD25bright频率(t=4.481,P=0.000)、IL-10水平(t=-9.330,P=0.000)及蜕膜组织中CD4+CD25bright频率(t=-6.261,P=0.000)、CD4+CD25bright/CD4+t=-7.793,P=0.000)显著低于健康对照组,Logistic回归分析显示外周血CD4+CD25bright频率、蜕膜组织CD4+CD25bright频率、蜕膜组织CD4+CD25bright/CD4+、外周血IL-10是流产发生的独立保护因素。结论: CD4+CD25+Treg细胞和IL-10在妊娠免疫调节中具有重要作用,其水平的降低与复发性流产的发生有关。

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