目的： 探究复发性流产与孕早期调节性T细胞及白介素-10（IL-10）水平的相关性。方法： 选取2016年3月至2017年12月于我院就诊的早期流产的复发性流产患者22例为复发性流产组，选择同期正常早孕但要求终止妊娠的患者37例为健康对照组，对比两组外周血及蜕膜组织中CD4⁺CD25^bright频率、CD4⁺CD25^dim频率、CD4⁺CD25^bright/CD4⁺及外周血中IL-10水平，应用Logistic回归分析复发性流产的独立危险因素。结果： 复发性流产组外周血中CD4⁺CD25^bright频率（t=4.481，P=0.000）、IL-10水平（t=-9.330，P=0.000）及蜕膜组织中CD4⁺CD25^bright频率（t=-6.261，P=0.000）、CD4⁺CD25^bright/CD4⁺（t=-7.793，P=0.000）显著低于健康对照组，Logistic回归分析显示外周血CD4⁺CD25^bright频率、蜕膜组织CD4⁺CD25^bright频率、蜕膜组织CD4⁺CD25^bright/CD4⁺、外周血IL-10是流产发生的独立保护因素。结论： CD4⁺CD25⁺Treg细胞和IL-10在妊娠免疫调节中具有重要作用，其水平的降低与复发性流产的发生有关。

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