Objective: To observe the efficacy of Escitalopram in treating patients with cardiac syndrome X(CSX) combined anxiety and depression. Methods: A total of 96 CSX patients combined with anxiety and depression admitted to the Department of Cardiology, Luoyang Central Hospital Affiliated to Zhengzhou University from October 2013 to February 2018 were randomly divided into treatment group and control group,with 48 cases in each group. Both groups received conventional treatment, and the treatment group was additionally treated with Escitalopram tablets, 10 mg once a day for a total of 6 months. The reduction of Hamilton Rating Scale for Anxiety (HAMA) and 17 items Hamilton Rating Scale for Depression (HAMD17) after treatment, the rate of re-hospitalization, the rate of tread mill exercise test, the time from the start of exercise test to the positive exercise test, blood routine, endothelin-1 level and other indicators in the two groups were observed respectively. Results: After treatment,HAMA score reduction (10.26±3.56) and HAMD17 score reduction (8.5±4.12) in the treatment group were significantly higher than those in the control group (P<0.05). Compared with the state before the treatment, the time from the start of the exercise test to the positive exercise test was longer in both groups,but the effect of the treatment group was better than control group.During the follow-up period, the readmission rate of the treatment group was 2.12%,which was significantly different from that of the control group (13.04%,P<0.05). No serious adverse reactions was observed in the treatment group.Conclusion: ForCSX patients combined with anxiety and depression,the addition of Escitalopram on the basis of conventional treatment can significantly improve the psychological state of patients,improve exercise tolerance,reduce the readmission rate. |
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