华蟾素胶囊联合羟基喜树碱对中晚期食管癌疼痛患者的疗效分析-现代医学

华蟾素胶囊联合羟基喜树碱对中晚期食管癌疼痛患者的疗效分析

单位：西电集团医院消化内分泌科, 陕西西安 710077

分类号：R735.1;R273

出版年·卷·期（页码）：2019·38·第十一期（1333-1336）

摘要：

目的：研究华蟾素胶囊联合羟基喜树碱用于中晚期食管癌的疗效。方法：选取2015年1月至2017年5月收治的120例食管癌患者作为研究对象，将患者依照治疗方案分为对照组和治疗组，每组60例。对照组给予羟基喜树碱，治疗组在此基础上每日给予华蟾素胶囊，比较两组患者客观缓解率、临床获益率、疼痛程度、生活质量和毒副作用，并对比两组患者治疗前后肿瘤标志物水平和1年存活率差异。结果：治疗后治疗组临床获益率、客观缓解率、生活质量显著高于对照组，疼痛程度显著轻于对照组，差异均有统计学意义（P<0.05）；两组患者CEA、CA19-9和CA72-4水平改善显著优于治疗前，治疗组显著优于对照组，差异均有统计学意义（P<0.05）；两组1年存活率、毒副作用方面比较，差异无统计学意义（P>0.05）。结论：华蟾素胶囊联合羟基喜树碱用于治疗中晚期食管癌疼痛，具有较好的临床效果，能够有效提高患者生活质量和临床获益率，改善肿瘤标志物水平，减轻癌痛程度，安全性较高，值得临床推广。

Objective: To study the efficacy of Cinobufagin capsule combined with hydroxycamptothecin in the treatment of patients with advanced esophageal cancer. Methods: 120 patients with esophageal cancer in our hospital from January 2015 to May 2017 were selected as the study subjects. All patients were divided into control group and treatment group according to the treatment plan, 60 cases in each. The patients in the control group were given hydroxycamptothecin, on top of which, the treatment group was given Cinobufagin capsule daily. The objective remission rate, clinical benefit rate, pain degree, quality of life and side effects were compared between the two groups. The level of tumor markers and 1-year survival rate of the two groups were compared before and after treatment. Results: After treatment, the clinical benefit rate, objective remission rate and quality of life of the treatment group were significantly higher than those of the control group. The pain degree of the treatment group was significantly lighter than that of the control group, and the difference was statistically significant (P<0.05); after treatment, the two groups of patients with CEA, CA19-9 and CA72-4 were significantly better than those before the treatment. The level of tumor markers in the treatment group was significantly better than that in the control group (P<0.05), and there was no significant difference in the 1 year survival rate and the side effects in the two groups (P>0.05). Conclusion: Cinobufagin capsule combined with hydroxycamptothecin has good clinical efficacy in the treatment of patients with advanced esophageal cancer. It can effectively improve the quality of life and the rate of clinical benefit, improve the level of tumor markers, reduce the degree of cancer pain and have high safety, which is worthy of clinical promotion.

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