Objective: To explore the value of intensive acid suppression in elderly patients with acute non-variceal upper gastrointestinal hemorrhage (ANVUGIB) treated by endoscopic hemostasis. Methods: 106 elderly patients with ANVUGIB admitted from March 2016 to March 2018 were randomly divided into a control group of 53 patients and an observation group of 53 patients, who all underwent endoscopic hemostasis treatment. The control group combined with conventional acid suppression program, the observation group combined with enhanced acid suppression program. The clinical effects of the two groups, treatment related indicators, serum urea nitrogen (BUN), hematocrit after treatment, 72 h after treatment (Hct) level changes and prognosis outcomes were observed. Results: The total effective rate of the observation group was 98.11%, which was statistically significant compared with the control group 84.91% (P<0.05).The hemostasis time, the time of hematemesis, the time of disappearance of melena and the length of hospital stay in the observation group were significantly shorter than those in the control group. The blood transfusion volume was significantly less than that of the control group, and the difference was statistically significant (P<0.05).There was no significant difference in serum BUN and Hct levels between the two groups before treatment (P>0.05).After 72 hours of treatment, the serum BUN and Hct levels in the observation group were compared with the control group (P<0.05).The incidence of adverse reactions in the observation group was 13.21%, and the mortality was 1.89%. Compared with the control group of 9.43% and 7.55%, the difference was not statistically significant (P>0.05).The rebleeding rate of the observation group was 1.89%, which was significantly higher than that of the control group 13.21% (P<0.05). Conclusion: The enhanced acid suppression program is applied to the elderly ANVUGIB for endoscopic hemostasis. The effect is significant, the rate of rebleeding is low, and the serum BUN and Hct levels can be significantly adjusted, and the safety is high, thus it is worthy of promotion.
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