Objective: To evaluate the expression and clinical significance of serum pentraxin-3 (PTX3) in patients with rheumatoid arthritis (RA). Methods: Consecutive selection 58 RA patients and 58 age- and gender- matched healthy controls (HC) from the Second Hospital of Yulin from January 2015 to December 2017 were enrolled in our study. Demographic data, clinical data and serum of RA patients were collected. The levels of serum PTX3 were measured by ELISA. Correlation analysis between serum PTX3 levels and laboratory parameters was also performed. Results: The levels of serum PTX3 were significantly increased in RA patients compared to HC (P<0.05). In addition, the levels of serum PTX3 were significantly higher in active RA patients than those in inactive stage (P<0.05). Correlation analysis showed that the levels of serum PTX3 were positively correlated with hypersensitive C-reactive protein (Hs-CRP) and DAS28 (r value was 0.400, 0.372, respectively, all P<0.05), but not correlated with erythrocyte sedimentation rate (ESR) (P>0.05). Furthermore, the results of ROC curve analysis showed that PTX3 in the diagnosis of RA, the sensitivity and specificity, and the area under curve (AUC) were 77.9%, 74.0% and 0.797, respectively. The sensitivity and specificity of PTX3 in distinguishing active and inactive RA were 64.5%, 74.1%, and the AUC was 0.731%, respectively. Conclusion: The levels of serum PTX3, associated with the disease activity, are significantly higher in patients with RA. PTX3 can be used as a novel biomarker for RA.
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