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熊去氧胆酸治疗原发性胆汁性胆管炎效果的评判
作者:王璐  孙可帅  田思远  张苗  韩英 
单位:空军军医大学西京医院 消化内科, 陕西 西安 710032
关键词:原发性胆汁性胆管炎 生物化学应答 熊去氧胆酸 
分类号:R453.9
出版年·卷·期(页码):2019·38·第十一期(1301-1305)
摘要:

目的:采用多种疗效判定标准,分析熊去氧胆酸(UDCA)治疗原发性胆汁性胆管炎(PBC)的临床效果。方法:回顾性研究初次接受UDCA治疗的466例PBC患者,收集患者治疗前和治疗1年内的临床相关资料,对患者治疗后的血清生化指标和生化应答率进行对比分析。结果:UDCA治疗1年后患者总体血清生化指标明显改善,依据不同疗效判定标准所得的生化应答率分别为64.38%(Barcelona标准)、57.73%(Paris 1标准)、44.64%(Paris 2标准)、32.19%(Ehime标准)、54.29%(Momah/Lindor标准)和86.91%(Rotterdam标准),进一步分析发现Paris 1标准、Paris 2标准和Momah/Lindor标准的应答符合率最高。结论:应采用多种标准综合评判UDCA的临床疗效。

Objective: To analyze the clinical efficacy of ursodeoxycholic acid(UDCA) in the treatment of primary biliary cholangitis(PBC) using different criteria to assess response to therapy. Methods: A total of 466 naive PBC patients were retrospectively reviewed. Changes in clinical features and biochemistries after therapy were assessed. Results: After 1 year of UDCA treatment, the overall blood biochemical parameters of the patients were improved significantly. The biochemical response rates according to different criteria were 64.38%(Barcelona criteria), 57.73%(Paris 1 criteria), 44.64%(Paris 2 criteria), 32.19%(Ehime criteria), 54.29%(Momah/Lindor criteria) and 86.91%(Rotterdam criteria) respectively. Further analysis found that the Paris 1, Paris 2 and Momah/Lindor criteria had the highest consistency rates. Conclusion: Multiple criteria should be used in combination to assess the response to UDCA therapy.

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