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非酒精性脂肪肝对老年2型糖尿病患者心脏结构和功能的影响
作者:冯艳伟  刘丹丹  李阔  李曼  杨海燕  崔雯霞  高蕾  胡云 
单位:南京大学医学院附属鼓楼医院 老年科, 江苏 南京 210008
关键词:2型糖尿病 非酒精性脂肪肝 心脏结构 心脏舒张功能 
分类号:R587.1;R575.5
出版年·卷·期(页码):2019·38·第十期(1236-1240)
摘要:

目的:探讨非酒精性脂肪肝(NAFLD)对老年2型糖尿病患者心脏结构和功能的影响。方法:收集2015年1月至2017年12月在我院老年科住院年龄≥ 60岁的2型糖尿病患者702例,根据腹部彩超结果分为无NAFLD组489例和NAFLD组213例,比较两组间超声心动图各指标的差异。结果:与无NAFLD组相比,NAFLD组患者室间隔及左心室后壁厚度明显增厚,左心室质量明显增大,分别为(0.98±0.01)vs(0.91±0.01)cm、(0.96±0.01)vs(0.89±0.01)cm、(176.62±2.58)vs(159.75±1.69)g,经多变量校正后差异仍具有统计学意义(P<0.05);与无NAFLD组相比,NAFLD组E波峰值流速(E)与A波峰值流速(A)的比(E/A)值<1的发生率显著升高;二元Logistic回归分析显示,NAFLD是心脏舒张功能障碍的独立危险因素。结论:老年2型糖尿病患者中NAFLD与室间隔厚度、左心室后壁厚度、左心室质量及心脏舒张功能障碍的患病风险呈显著正相关。

参考文献:

[1] TARGHER G,BYRNE C D.Clinical review:nonalcoholic fatty liver disease:a novel cardiometabolic risk factor for type 2 diabetes and its complications[J].J Clin Endocrinol Metab,2013,98:483-495.
[2] ANSTEE Q M,TARGHER G,DAY C P.Progression of NAFLD to diabetes mellitus,cardiovascular disease or cirrhosis[J].Nat Rev Gastroenterol Hepatol,2013,10:330-344.
[3] PSYCHARI S N,REKLEITI N,PAPAIOANNOU N,et al.Epicardial fat in nonalcoholic fatty liver disease:properties and relationships with metabolic factors,cardiac structure,and cardiac function[J].Angiology,2016,27(1):41-48.
[4] BALLESTRI S,LONARDO A,BONAPACE S,et al.Risk of cardiovascular,cardiac and arrhythmic complications in patients with non-alcoholic fatty liver disease[J].World J Gastroenterol,2014,20:1724-1745.
[5] 中华医学会肝脏病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪性肝病诊疗指南[J].中华肝脏病杂志,2006,14:161-163.
[6] DEVEREUX R B,ALONSO D R,LUTAS E M,et al.Echocardiographic assessment of left ventricular hypertrophy:comparison to necropsy findings[J].Am J Cardiol,1986,57(6):450-458.
[7] PRIVITERA G,SPADARO L,ALAGONA C,et al.Hepatic insulin resistance in NAFLD:relationship with markers of atherosclerosis and metabolic syndrome components[J].Acta Diabetol,2016,53(3):449-459.
[8] HALLSWORTH K,HOLLINGSWORTH K G,THOMA C,et al.Cardiac structure and function are altered in adults with non-alcoholic fatty liver disease[J].J Hepatol,2013,58(4):757-762.
[9] PETTA S,ARGANO C,COLOMBA D,et al.Epicardial fat,cardiac geometry and cardiac function in patients with nonalcoholic fatty liver disease:association with the severity of liver disease[J].J Hepatol,2015,62(4):928-933.
[10] BONAPACE S,PERSEGHIN G,MOLON G,et al.Nonalcoholic fatty liver disease is associated with left ventricular diastolic dysfunction in patients with type 2 diabetes[J].Diabetes Care,2012,35(2):389-395.
[11] CASSIDY S,HALLSWORTH K,THOMA C,et al.Cardiac structure and function are altered in type 2 diabetes and non-alcoholic fatty liver disease and associate with glycemic control[J].Cardiovasc Diabetol,2015,14:23.
[12] CHENG S,XANTHAKIS V,SULLIVAN L M,et al.Correlates of echocardiographic indices of cardiac remodeling over the adult life course longitudinal observations from the Framingham Heart Study[J].Circulation,2010,122(2):570-578.
[13] JORGENSEN P G,JENSEN M T,MOGELVAN R,et al.Impact of type 2 diabetes and duration of type 2 diabetes on cardiac structure and function[J].Int J Cardiol,2016,21:114-221.
[14] WONG C K,BURGESS M I,IRWIN A,et al.Evidence of diastolic dysfunction in NAFLD:a study using tissue doppler echocardiography[J].Diabetologia,2010,53:S495-S496.

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