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非酒精性脂肪肝对老年2型糖尿病患者心脏结构和功能的影响
作者:冯艳伟  刘丹丹  李阔  李曼  杨海燕  崔雯霞  高蕾  胡云 
单位:南京大学医学院附属鼓楼医院 老年科, 江苏 南京 210008
关键词:2型糖尿病 非酒精性脂肪肝 心脏结构 心脏舒张功能 
分类号:R587.1;R575.5
出版年·卷·期(页码):2019·38·第十期(1236-1240)
摘要:

目的:探讨非酒精性脂肪肝(NAFLD)对老年2型糖尿病患者心脏结构和功能的影响。方法:收集2015年1月至2017年12月在我院老年科住院年龄≥ 60岁的2型糖尿病患者702例,根据腹部彩超结果分为无NAFLD组489例和NAFLD组213例,比较两组间超声心动图各指标的差异。结果:与无NAFLD组相比,NAFLD组患者室间隔及左心室后壁厚度明显增厚,左心室质量明显增大,分别为(0.98±0.01)vs(0.91±0.01)cm、(0.96±0.01)vs(0.89±0.01)cm、(176.62±2.58)vs(159.75±1.69)g,经多变量校正后差异仍具有统计学意义(P<0.05);与无NAFLD组相比,NAFLD组E波峰值流速(E)与A波峰值流速(A)的比(E/A)值<1的发生率显著升高;二元Logistic回归分析显示,NAFLD是心脏舒张功能障碍的独立危险因素。结论:老年2型糖尿病患者中NAFLD与室间隔厚度、左心室后壁厚度、左心室质量及心脏舒张功能障碍的患病风险呈显著正相关。

参考文献:

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