Objective:To investigate the effect of low-dose fluticasone propionate inhalation on pulmonary function, bone metabolism, bone density, growth and development in children with bronchial asthma.Methods:Forty children with moderate persistent bronchial asthma treated with continuous inhalation of low dose fluticasone propionate aerosol for one year were served as therapeutic group, while 40 children of normal physical examination in the same period were selected as control group. Changes in pulmonary function, bone metabolism, bone density and growth and development in the two groups were compared and observed.Results:Repeated determination of FVC, FEV1/FVC and PEF at the same time point before and after treatment showed that there were interactions between the groups and time points(P<0.05). The levels of FEV1/FVC and PEF in the therapeutic group were significantly lower than those in the control group(P<0.05). There were no significant changes in serum calcium, serum phosphorus, alkaline phosphatase, osteocalcin and bone mineral density in the therapeutic group(P>0.05). And there were no significant changes in height and weight in the two groups. Conclusion:Long-term low-dose inhalation of fluticasone propionate aerosol for children with bronchial asthma is effective, and has no adverse effects on bone metabolism, bone density and growth development.
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