Objective:To summarize the clinical features of chemotherapy-induced liver injury(CILI) in breast cancer patients, and to analyze its related influencing factors.Methods:Five hundred and forty-nine breast cancer patients admitted to our hospital and treated with adjuvant chemotherapy from March 2015 to March 2018 were selected. The incidence and clinical characteristics of CILI, and its related influencing factors were investigated and studied.Results:(1) The incidence of liver injury in 549 patients treated with adjuvant chemotherapy for breast cancer was 15.7%, including 69 cases of gradeⅠ, 15 of grade Ⅱ and 2 of grade Ⅲ. (2) CILI occurred in 14 cases of the first cycle, 47 of the second, 23 of the third and in 2 cases of the fourth cycle and over. (3) The incidence of CILI was not significantly correlated with age, mass size,tumor type,axillary lymph node metastasis, histological grade,clinical stage, myelosuppression, hepatitis B virus carriers, hypertension, diabetes, body mass index, smoking and alcohol consumption(P>0.05). Patients with hyperlipidemia, liver metastasis and three-drug combination chemotherapy were more likely to develop CILI(P<0.05). Conclusion:Liver injury of grade I is mainly found in patients treated with adjuvant chemotherapy for breast cancer, its incidence is not high and is prone to occur in the secondcycles of chemotherapy. Three-drug combination chemotherapy should not be conducted in patients with hyperlipidemia and liver metastases.
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