目的：耳鸣异响是由丘脑和大脑皮层的异常功能连接引起的，为了探讨这一假设，我们使用静息态功能磁共振成像对慢性耳鸣患者和正常对照者丘脑功能连接情况进行比较。方法：对30例慢性耳鸣患者和30例健康对照者进行静息态功能磁共振成像扫描。丘脑功能连接使用的是基于全脑的种子点功能连接法，分别以左、右侧丘脑为种子点得到丘脑功能连接性指标。结果：耳鸣患者双侧中央前回及左侧梭状回与左丘脑种子区之间的功能连接增强，右侧颞中回及左侧小脑后叶与左丘脑种子区功能连接降低；右侧颞中回及左侧小脑后叶与右丘脑种子区之间的功能连接增强，右侧中央前回与右侧丘脑种子区之间的功能连接降低。结论：慢性耳鸣患者中与耳鸣特点相关特定脑区与丘脑间功能连接异常，静息状态丘脑功能连接的异常可能在耳鸣的病理生理学机制中发挥重要作用。

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