肝素结合蛋白（HBP）是中性粒细胞胞浆中的颗粒蛋白，它在重症细菌感染的病理生理学上具有重要作用，是新颖的诊断标志物和治疗疾病的靶点。从生物学上讲，HBP是一种早期的感染预测性生物标志物，它能够快速动员中性粒细胞来应对细菌感染；同时，HBP也可诱导血管渗漏和水肿形成，引起血管屏障功能失调和细胞炎症反应，最终导致器官功能障碍。作者对HBP在脓毒症、心肺复苏术后、急性肾损伤、急性呼吸窘迫综合征、急性细菌性脑膜炎等中的作用研究进展作一综述。

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