马来酸噻吗洛尔滴眼液联合超脉冲CO<sub>2</sub>点阵激光治疗婴幼儿皮肤血管瘤的疗效分析-现代医学

马来酸噻吗洛尔滴眼液联合超脉冲CO₂点阵激光治疗婴幼儿皮肤血管瘤的疗效分析

单位：1. 保定市儿童医院皮肤科, 河北保定 071000;
2. 保定市儿童呼吸消化疾病临床研究重点实验室, 河北保定 071000;
3. 石家庄市栾城人民医院普外科, 河北石家庄 051430;
4. 保定市第一医院皮肤科, 河北保定 071000

关键词：血管瘤马来酸噻吗洛尔滴眼液 CO₂点阵激光疗效婴幼儿

分类号：R751.05;R732.2

出版年·卷·期（页码）：2019·47·第七期（835-838）

摘要：

目的：探讨马来酸噻吗洛尔滴眼液联合超脉冲CO₂点阵激光治疗婴幼儿皮肤血管瘤的临床疗效。方法：将100例皮肤血管瘤患儿随机分为对照组和观察组，各50例。对照组采用马来酸噻吗洛尔滴眼液局部外用治疗，观察组采用马来酸噻吗洛尔滴眼液联合CO₂点阵激光治疗，比较两组临床疗效、平均治疗时间及不良反应发生情况。结果：观察组治愈22例，显效17例，总有效率为78%，平均治愈时间（1.92±0.95）个月。对照组治愈11例，显效18例，总有效率为58%，平均治愈时间（2.76±1.43）个月。观察组患儿总有效率明显高于对照组，差异有统计学意义（P<0.05）；观察组患儿平均治愈时间短于对照组，但差异无统计学意义（P>0.05）。结论：马来酸噻吗洛尔滴眼液联合超脉冲CO₂点阵激光可有效提高婴幼儿皮肤血管瘤的治疗效果，相对缩短治疗时间，且无明显不良反应，值得在临床上应用与推广。

Objective:To investigate the curative effect of timolol maleate eye drops combined with CO₂ ultrapulse fractional laser in treatment of children with hemangioma. Methods:One hundred children with hemangioma were randomly divided into the control and the observation group with 50 cases in each group. The control group received timolol maleate eye drops local application, while the observation group received timolol maleate eye drops combined with CO₂ ultrapulse fractional laser. The curative effect, average curing time and incidence condition of adverse reaction of the two groups were compared. Results:Among the 50 children in observation group, 22 were cured, 17 were developed, and the total effective rate was 78%, the average curing time was (1.92±0.95) months. And among the 50 children in control group, 11 were cured, 18 were developed, and the total effective rate was 58%, the average curing time was (2.76±1.43) months. The total effective rate of the children in the observation group were significantly higher than that of the control group(P<0.05).The average curing time was shorter than that of the control group,but there was no significant difference (P>0.05).Conclusion:Timolol maleate eye drops combined with CO₂ ultrapulse fractional laser is effective in improving the therapeutic effect of children with hemangioma, relatively shortening the treatment time, and there is no obvious adverse reaction.It is worthy of clinical application and promotion.

参考文献：

[1] 王佳,石静,王绪凯.0.5%马来酸噻吗洛尔溶液联合普萘洛尔治疗婴幼儿血管瘤的不良反应观察[J].中国口腔颌面外科杂志,2014,12(6):539-542.
[2] 金云波,林晓曦,叶肖肖,等.普萘洛尔作为严重婴幼儿血管瘤一线治疗的前瞻性研究[J].中华整形外科杂志,2011,27(3):170-173.
[3] 钟益萍,孙乐栋.血管瘤外用药物治疗的研究进展[J].中国美容医学,2013,22(1):229-231.
[4] 中华医学会整形外科分会血管瘤和脉管畸形学组.血管瘤和脉管畸形诊断和治疗指南(2016版)[J].组织工程与重建外科杂志,2016,12(2):63-93,97.
[5] 马琳.儿童皮肤病学[M].北京:人民卫生出版社,2014:156-166.
[6] LUU M,FRIEDEN I J.Haemangioma:clinical course, complications and management[J].Br J Dermatol,2013,169(1):20-30.
[7] 中华口腔医学会,口腔颌面外科专业委员会,脉营性疾病学.口腔颌面部血管瘤及脉管畸形的诊断和治疗指南(草案)[J].中华口腔医学杂志,2005,40(3):185-186.
[8] 郑家伟,张凌.婴幼儿血管瘤治疗理念与方法的转变[J/OL].中华口腔医学研究杂志(电子版),2015,9(2):91-94.
[9] 郑家伟,马坤宁,张凌.婴幼儿血管瘤药物治疗概述[J].中国口腔颌面外科杂志,2014,12(1):1-6.
[10] BRUSCINO N,BONAN P,CANNAROZZO G,et al.Laser use in infantile hemangiomas,when and how[J].Dermatol Ther,2012,25(4):314-321.
[11] 夏学颖,孙赛,张碧芳,等.马来酸噻吗洛尔滴眼液联合强脉冲光治疗婴幼儿表浅血管瘤的疗效观察[J].中国医药科学,2017,7(12):28-32.
[12] GUO S,NI N.Topical treatment for capillary hemangioma of the eyelid using beta-blocker solution[J].Arch Ophthalmol,2010,128(2):255-256.
[13] LÉAUTÉ-LABRÈZE C,DUMAS DE LA ROQUE E, HUBICHE T,et al.Propranolol for severe hemangiomas of infancy[J].N Engl J Med,2008,358(24):2649-2651.
[14] 冯先才,吴雪花,王朝华,等.点阵激光联合中药敷贴治疗瘢痕疙瘩58例[J].河南中医,2016,36(11):2000-2002.
[15] 陈小静.曲安奈德注射液联合CO₂点阵激光治疗瘢痕疙瘩的临床疗效[J].包头医学院学报,2017,33(5):67-68.
[16] 曹玉婷,孙立.点阵激光辅助药物传输的研究进展[J].中国激光医学杂志,2017,26(1):30-33.

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