高血尿酸水平与高脂血症的相关性研究-现代医学

高血尿酸水平与高脂血症的相关性研究

单位：1. 青海省交通医院急诊科, 青海西宁 810000;
2. 新乡医学院临床医学院, 河南新乡 453003

分类号：R781.63

出版年·卷·期（页码）：2019·47·第七期（801-804）

摘要：

目的：探究高血尿酸水平与血脂异常之间的相关性。方法：以2012年6 382例体检者为研究对象，排除高血压病、糖尿病、高血脂、慢性肾病者，5年后再次行体检评估，根据基线血尿酸（SUA）水平将受试者分为正常尿酸组和高尿酸血症组。应用多元逻辑回归模型，在校正年龄、体质量、抽烟、饮酒等因素后，分析基线SUA水平及5年内SUA水平升高与低密度脂蛋白（LDL）及甘油三酯（TG）水平升高之间的相关性。结果：所有受试者5年内发生高LDL、低HDL、高TG的风险分别为10.8%、2.1%、11.4%，5年内总的血脂异常发生率为24.7%。单因素和多因素回归分析表明，较高的基线SUA水平、5年内SUA水平升高与高LDL、高TG血症的发生具有明显的关联性。结论：临床上无症状的高SUA可能是高LDL和高TG血症发生发展潜在的危险因素。

Objective:To explore the correlation between hyperuricemia and dyslipidemia. Methods:A total of 6 382 physical examination subjects in 2012 were enrolled into this study, excluding baseline hypertension, diabetes mellitus, hyperlipidemia and chronic kidney disease. After 5 years, physical examination was conducted again. According to baseline serum uric acid (SUA) level, the subjects were divided into normal uric acid group and hyperuricemia group. Multivariate Logistic regression model was used to analyze the correlation between baseline SUA level, 5-year SUA level change and elevated levels of low density lipoprotein (LDL) cholesterol and triglyceride (TG) after adjusting for age, body mass, smoking and alcohol consumption. Results:The risk of high LDL, low HDL and high TG were 10.8%, 2.1%, 11.4%, respectively in the subjects within 5 years, and the total incidence of dyslipidemia within 5 years was 24.7%. Univariate and multivariate regression analysis showed that high baseline SUA level and 5-year increase in SUA were significantly associated with high LDL cholesterol and high TG. Conclusion:Asymptomatic hyperuricemia may be a potential risk factor for the occurrence and development of high LDL cholesterol and hypertriglyceridemia.

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