Objective:To explore the correlation between hyperuricemia and dyslipidemia. Methods:A total of 6 382 physical examination subjects in 2012 were enrolled into this study, excluding baseline hypertension, diabetes mellitus, hyperlipidemia and chronic kidney disease. After 5 years, physical examination was conducted again. According to baseline serum uric acid (SUA) level, the subjects were divided into normal uric acid group and hyperuricemia group. Multivariate Logistic regression model was used to analyze the correlation between baseline SUA level, 5-year SUA level change and elevated levels of low density lipoprotein (LDL) cholesterol and triglyceride (TG) after adjusting for age, body mass, smoking and alcohol consumption. Results:The risk of high LDL, low HDL and high TG were 10.8%, 2.1%, 11.4%, respectively in the subjects within 5 years, and the total incidence of dyslipidemia within 5 years was 24.7%. Univariate and multivariate regression analysis showed that high baseline SUA level and 5-year increase in SUA were significantly associated with high LDL cholesterol and high TG. Conclusion:Asymptomatic hyperuricemia may be a potential risk factor for the occurrence and development of high LDL cholesterol and hypertriglyceridemia.
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