Objective:To evaluate the neuroprotection and its safety of dexmedetomidine in patients with severe preeclampsia. Methods:Sixty patients with severe preelampsia scheduled for elective cesarean section under combined spinal-epidural analgesia were randomly divided intothe dexmedetomidine group and the control group, 30 cases each group. The dexmedetomidine group received a loading dose of dexmedetomidine 0.5 μg·kg-1 at 10 min after delivery of the fetus, followed by infusion at a rate of 0.5 μg·kg-1·h-1 until the end of operation, while the control group were treated with equivalent normal saline. The levels of serum S100β and NSE of the patieuts in the two groups were recorded before the anesthesia(T1), at the completion of operation(T2), 6 h after operation(T3), 12 h after operation(T4) and 24 h after operation(T5),repectively.At the same time, complications and hemodynamic responses were detected. The cognitive function was assessed at 1 d before operation and 1,3 dafter operation by mini-mental state examination(MMSE),repectively. Results:Compared with the control group,the levelof S100β in the dexmedetomidine group at T3, T4,T5 time points were decreased (P<0.05). The levelof NSE in the dexmedetomidine group at T4,T5 time points were lower than those of the control group(P<0.05). Compared with the control group, the lasting time of dizziness, blurred vision of the dexmedetomidine group were significantly shorter(P<0.05) and the occurrence of hypotension and the use of anti-hypertensive drugs were decreased(P<0.05).There were no significant differences in bradycardia, duration of postoperative headache, MMSE score and postoperative hospital stay(P>0.05). Conclusion:Intravenous infusion of dexmedetomidine after delivery of the fetus can reduce serum S100β protein and NSE levels in patients with severe preeclampsia, reduce perioperative blood pressure fluctuations and the incidence of complications. Dexmedetomidine can provide neuroprotection.
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